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Negatively regulates growth hormone (GH) receptor cell surface expression in liver. Additionally we are shipping LEPROTL1 Proteins (3) and many more products for this protein.
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Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 (show MBOAT4 Antibodies) and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
the increased expression of FGF21 (show FGF21 Antibodies) during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT (show LEPR Antibodies) and LEPROTL1.
both LEPROT and LEPROTL1 expression were regul (show LEPR Antibodies)ated in liver by physiologic and pathologic changes in glucose homeo (show IGF1 Antibodies)stasis
Transgenic mice expressing either human LEPROT (show LEPROT Antibodies) or human LEPROTL1 displayed growth retardation, reduced plasma IGF1 (show IGF1 Antibodies) levels, and impaired hepatic sensitivity to GH, as measured by STAT5 (show STAT5A Antibodies) phosphorylation and Socs2 (show SOCS2 Antibodies) mRNA expression.
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
leptin receptor overlapping transcript-like 1
, Leptin receptor overlapping transcript-like 1