anti-Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1) Antibodies

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity). Additionally we are shipping LINGO1 Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LINGO1 84894 Q96FE5
LINGO1 235402 Q9D1T0
LINGO1 315691  
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Top anti-LINGO1 Antibodies at antibodies-online.com

Showing 10 out of 128 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of LINGO1 Antibody (N-term) (ABIN652312) in mouse cerebellum tissue lysates (35 µg/lane). LINGO1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of LINGO-1(LRRN6A)(ABIN651289) in mouse liver tissue lysates (35 µg/lane).LRRN6A (arrow) was detected using the purified polyclonal antibody. LINGO-1(LRRN6A)-S596 (C-term) Antibody (ABIN651289) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of LINGO1 (arrow) using rabbit polyclonal LINGO1 Antibody (N-term) (ABIN391440).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 Antibody (N-term) (ABIN391440), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Chicken Rabbit Un-conjugated IHC, IHC (p) Anti-LINGO1 antibody  ABIN1049010 IHC staining of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-LINGO1 antibody IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-LINGO1 antibody  ABIN1049009 IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-LINGO-1(LRRN6A)-pS596 Pab (ABIN650826) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with LINGO1 antibody ABIN239799 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-LINGO1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated CyTOF, FACS, ICC Detection of LINGO-1 in CHP-100 Human Cell Line by Flow Cytometry. CHP-100 human neuro-blastoma cell line was stained with Mouse Anti-Human LINGO-1 Mono-clonal Antibody. 100 μg Log in to see 8 to 9 Days
$238.43
Details
Bat Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: LINGO-1 Antibody [NBP1-39603] - Analysis of anti-LINGO1 antibody with human brain, cortex at concentration 20 ug/ml. 0.05 mL Log in to see 10 to 13 Days
$516.98
Details

Top referenced anti-LINGO1 Antibodies

  1. Human Polyclonal LINGO1 Primary Antibody for IHC (p), ELISA - ABIN543819 : Satoh, Tabunoki, Yamamura, Arima, Konno: TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. in Neuropathology and applied neurobiology 2007 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal LINGO1 Primary Antibody for IHC (p), WB - ABIN651289 : Towner, Jensen, Vaillant, Colman, Saunders, Giles, Wren: Experimental validation of 5 in-silico predicted glioma biomarkers. in Neuro-oncology 2013 (PubMed)

  3. Human Monoclonal LINGO1 Primary Antibody for CyTOF, FACS - ABIN4900323 : Meabon, De Laat, Ieguchi, Wiley, Hudson, Bothwell: LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments. in The Journal of biological chemistry 2015 (PubMed)

More Antibodies against LINGO1 Interaction Partners

Human Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1) interaction partners

  1. We identified homozygous missense variants in LINGO1, p.(Arg290His) in family F162 and p.(Tyr288Cys) in family PKMR65. Both variants were predicted to be pathogenic, and segregated with the phenotype in the respective families. Molecular modeling of LINGO1 suggests that both variants interfere with the glycosylation of the protein.

  2. LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Chinese population.

  3. LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells.

  4. Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR).

  5. The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients.

  6. Lingo-1 signaling is altered in the schizophrenia brain.

  7. LINGO-1 can directly bind to ErbB2, block ErbB2 translocation into lipid rafts, and inhibit its phosphorylation.

  8. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.

  9. LINGO1 variants are associated with essential tremor in Chinese Han female patients.

  10. This study demonistrated that theLINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis.

  11. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.

  12. Results of a meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and risk of essential tremor (ET) and familial ET, while rs9652490 polymorphism is only associated with the risk for familial ET.

  13. the N-terminal region containing the leucine-rich repeats along with the transmembrane and cytoplasmic domains of LINGO-1 are not required for self-interaction or interaction with amyloid precursor protein

  14. the present meta-analysis does not support the notion that LINGO1 rs9652490 SNP is a major genetic risk factor for parkinson disease.[meta-analysis]

  15. This study showed that LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease.

  16. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions

  17. There were no significant differences in frequencies for all alleles between the essential tremor (ET) group and controls; however, an association of genotype A/G of the SNP rs9652490 with the familial ET phenotype was found.

  18. Single nucleotide polymorphism(SNP)s of LINGO1 play a role in the development of Parkinson's disease in the Italian population.

  19. LINGO1 variants are not a major risk factor for developing familial essential tremor in this population, which suggests the existence of other genetic risk factors responsible for familial essential tremor in this movement disorder clinic population.

  20. while there were no significant differences in the Lingo1 minor allele frequency and genotype frequency between Chinese essential tremor and controls, pooled analysis showed a higher proportion of GG genotype in tremor patients

Mouse (Murine) Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1) interaction partners

  1. Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).

  2. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1

  3. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions

  4. a novel role for LINGO-1 in neural stem cell differentiation to neurons

  5. inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration

  6. Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.

LINGO1 Antigen Profile

Protein Summary

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (By similarity).

Gene names and symbols associated with LINGO1

  • leucine rich repeat and Ig domain containing 1 (LINGO1) antibody
  • leucine rich repeat and Ig domain containing 1 (lingo1) antibody
  • leucine rich repeat and Ig domain containing 1 (Lingo1) antibody
  • 4930471K13Rik antibody
  • AV148400 antibody
  • DKFZp459P0736 antibody
  • LERN1 antibody
  • LINGO-1 antibody
  • Lrrn6a antibody
  • UNQ201 antibody

Protein level used designations for LINGO1

leucine rich repeat and Ig domain containing 1 , leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 , Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 , leucine rich repeat neuronal 6A , leucine-rich repeat and immunoglobilin domain-containing protein 1 , leucine-rich repeat and immunoglobulin domain-containing protein 1 , leucine-rich repeat neuronal protein 1 , leucine-rich repeat neuronal protein 6A , leucine-rich repeat neuronal 6A , cLINGO-1

GENE ID SPECIES
453764 Pan troglodytes
100061441 Equus caballus
100101739 Xenopus (Silurana) tropicalis
100171931 Pongo abelii
100228050 Taeniopygia guttata
84894 Homo sapiens
235402 Mus musculus
415344 Gallus gallus
487660 Canis lupus familiaris
100155465 Sus scrofa
520694 Bos taurus
315691 Rattus norvegicus
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