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Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Additionally we are shipping Leukotriene A4 Hydrolase Antibodies (120) and Leukotriene A4 Hydrolase Kits (31) and many more products for this protein.
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lta4h mutations confer hypersusceptibility to mycobacterial infection by redirecting eicosanoid substrates to anti-inflammatory lipoxins.
Mutating F375 in xlLTA4H to tyrosine abolishes the formation of the LTB4 (show PTGR1 Proteins) isomeric product Delta(6)-trans-Delta(8)-cis (show CISH Proteins)-LTB4 (show PTGR1 Proteins).
The structures reveal that a single catalytic water is involved in both catalytic activities of LTA4H, alternating between epoxide ring opening and peptide bond hydrolysis, assisted by E271 and E296, respectively. Moreover, we have found two conformations of LTA4H, uncovering significant domain movements.
A higher incidence of severe IRIS among patients with mutant LTA4H genotypes (CT and TT) was observed compared to the wild type, despite similar IRIS incidence and immune restoration in both groups. Steroids were effective in alleviating IRIS in all the genotypes
The LTA4H promoter polymorphism correlated with CSF (show CSF2 Proteins) mononuclear cell count but not with mortality in tuberculous meningitis
LTA4H genotype predicted survival of HIV-uninfected patients, with TT-genotype patients significantly more likely to survive tuberculous meningitis than CC-genotype patients. LTA4H genotype and HIV infection influence pretreatment inflammatory phenotype and survival from tuberculous meningitis. LTA4H genotype may predict adjunctive corticosteroid responsiveness in HIV-uninfected individuals.
LTA4H promoter region SNP was associated with susceptibility to bacteriologically confirmed bacterial meningitis but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.
Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes.
The best proteinogenic amino acid recognized by LTA4H is arginine.
The results of our study failed to confirm whether the selected variants in LTA4H gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA (show ARSA Proteins).
The LTA4H A-9188>G polymorphism has a strong association with severe asthma in children.
Data indicate that 13S,14S-epoxy-docosahexaenoic acid (DHA) inhibits leukotriene B4 (LTB4 (show PTGR1 Proteins)) biosynthesis by leukotriene A4 hydrolase (LTA4H).
These findings indicate that LTA4H is critical for skin carcinogenesis and is an important mediator of cell cycle and the data begin to clarify the mechanisms of LTA4H's role in cancer development.
There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection.
CS exposure promotes the development of CS-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and neutrophils in the airspaces.
in acute neutrophil-driven lung inflammation, PGP was degraded by LTA(4)H which facilitated resolution of inflammation; cigarette smoke, a major risk factor for COPD,inhibited LTA(4)H aminopeptidase activity leading to accumulation of PGP and neutrophils
5-lipoxygenase (show ALOX5 Proteins) and leukotriene A4 hydrolase expression in atherosclerotic lesions correlates with symptoms of plaque instability
In the mouse nervous system ,Immunoreactivity for leukotriene A4 hydrolase showed widespread distribution with preference to the sensory-associated structures.
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
leukotriene A4 hydrolase
, leukotriene A-4 hydrolase
, Leukotriene A4 hydrolase
, leukotriene A-4 hydrolase-like
, LTA-4 hydrolase
, aminopeptidase T
, leukotriene A(4) hydrolase
, LTA4 hydrodase
, LTA4 hydrolase