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LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Lcor Antibodies (57) and Lcor Kits (4) and many more products for this protein.
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LCoR negatively regulates early adipogenesis by repressing C/EBP beta (show CEBPB Proteins) transcriptional activity and add LCoR to the growing list of transcriptional corepressors of adipogenesis.
miR (show MLXIP Proteins)-199a promotes stem cell properties in mammary stem cells and breast cancer stem cells by directly repressing nuclear receptor corepressor LCOR, which primes interferon (show IFNA Proteins) responses.
These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner.
identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed in various tissues other than testis
Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 (show NRIP1 Proteins) and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells.
LCoR recruitment by KLF6 (show KLF6 Proteins) regulates expression of the cyclin-dependent kinase (show CDK1 Proteins) inhibitor CDKN1A gene.
Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.
These results showed that the presence of miR (show MLXIP Proteins)-615-3p repressed the expression of LCoR, a derepressor of peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins)).
Data show that LCoR (ligand-dependent nuclear receptor corepressor) represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms [Ligand-dependent nuclear receptor corepressor].
HDAC6 (show HDAC6 Proteins) can function as a cofactor of LCoR but they can act to enhance expression of specific estrogen-regulated genes
role for LCoR and CtBP1 (show CTBP1 Proteins) as attenuators of progesterone-regulated transcription, but LCoR and CtBP1 (show CTBP1 Proteins) can act to enhance transcription of some genes
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003
, ligand-dependent corepressor
, mblk1-related protein 2
, transcription factor MLR2
, ligand dependent nuclear receptor corepressor