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The protein encoded by LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. Additionally we are shipping LDLRAP1 Antibodies (129) and LDLRAP1 Proteins (8) and many more products for this protein.
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LDLRAP1 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Numb (show NUMB ELISA Kits) specifically regulates NPC1L1 (show NPC1L1 ELISA Kits)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (show DAB2 ELISA Kits), which selectively participate in LDLR (show LDLR ELISA Kits)-mediated LDL uptake.
Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]
cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.
This work identified a combined LDL receptor (show LDLR ELISA Kits) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.
The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.
report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (show PTBP1 ELISA Kits)) domain of ARH in complex with an LDLR (show LDLR ELISA Kits) tail peptide containing the FxNPxY(0) internalization signal
LDL receptor (show LDLR ELISA Kits)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.
ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (show LMNB1 ELISA Kits) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.
Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (show LDLR ELISA Kits), which encodes only the FxNPxY motif (LDLR (show LDLR ELISA Kits)-CT27 (show CTCFL ELISA Kits)).
The combination of Arh and Dab2 (show DAB2 ELISA Kits) is responsible for the majority of adaptor function in LDLR (show LDLR ELISA Kits) endocytosis and LDLR (show LDLR ELISA Kits)-mediated cholesterol homeostasis.
results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (show LDLR ELISA Kits) endocytosis in the liver
Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (show LDLR ELISA Kits) is not cell-specific, but rather may depend on the cellular environment.
the LDL receptor (show LDLR ELISA Kits) alone can account for the clearance of apoE (show APOE ELISA Kits)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (show APOE ELISA Kits)-induced hypertriglyceridemia in mice.
Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.
the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis
Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (show LDLR ELISA Kits)
ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
low density lipoprotein receptor adaptor protein 1
, low-density lipoprotein adaptor protein
, low density lipoprotein receptor adapter protein 1
, LDL receptor adaptor protein
, autosomal recessive hypercholesterolemia protein
, autosomal recessive hypercholesterolemia protein homolog
, ARH beta
, autosomal recessive hypercholesterolemia protein homolog beta
, low density lipoprotein receptor adapter protein 1-B
, xARH beta
, ARH alpha
, autosomal recessive hypercholesterolemia protein homolog alpha
, low density lipoprotein receptor adapter protein 1-A
, phosphotyrosine binding protein
, phosphotyrosine-binding protein
, xARH alpha