Lysyl Oxidase-Like 1 Proteins (LOXL1)

LOXL1 encodes a member of the lysyl oxidase gene family. Additionally we are shipping LOXL1 Antibodies (83) and LOXL1 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LOXL1 4016 Q08397
LOXL1 16949 P97873
LOXL1 315714  
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Top LOXL1 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$733.00
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Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$765.00
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 Days
$411.40
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Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 Days
$581.90
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Yeast Mouse His tag 100 μg Log in to see 8 to 11 Days
$578.60
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$672.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,417.33
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

LOXL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) , ,
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Rat (Rattus)

More Proteins for Lysyl Oxidase-Like 1 (LOXL1) Interaction Partners

Rhesus Monkey Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. high lysyl oxidase activity is associated with ischemic hearts.

Human Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. LOXL1 variants that contribute to exfoliative glaucoma demonstrate various differences and are also common in normal population.

  2. LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer.

  3. The current study aimed to investigate the role of LOXL1 in liver fibrosis and the potential mechanism; the mRNA and protein levels of LOXL1 were increased in transforming growth factor-beta 1 (TGF-beta1)-stimulated human hepatic stellate cell line LX-2.

  4. the rs11638944:C>G transversion exerts a cis-acting effect on the expression levels of LOXL1, mediated by differential binding of the transcription factor retinoid X receptor alpha and by modulating alternative splicing of LOXL1, eventually leading to reduced levels of LOXL1 mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome

  5. LOXL1/LOXL2 gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.

  6. This study focused on the relationship between lysyl oxidase (LOX), LOX-like protein 1 (LOXL1), and LOXL2 and pulmonary emphysema pathogenesis.

  7. These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX-associated environmental and nutritional cues.

  8. remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP. The role of biopsy location on LOXL1 expression requires further investigation.

  9. In this study, we found no significant association between allele and genotype frequencies of APOE; the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.

  10. The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF in the South Indian population correlating with lowered LOX activity in the aqueous humor. The increased level of total TGF-beta in the aqueous humor of PXF cases is possibly associated with LOX regulation which needs further investigation.

  11. A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS. It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.

  12. Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.

  13. LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A was concomitantly overexpressed.

  14. The present study, for the first time, shows that the pseudoexfoliation syndrome-associated variant residues in LOXL1 influence processing of the protein, most likely by BMP-1.

  15. In this study group of Turkish population, no LOXL1 mutations were found. No associations between the defined SNPs (A320A, R141L and F184F) and the severity of the disease were detected.

  16. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue

  17. To identify additional candidate functional variants, we sequenced the entire LOXL1 genomic locus ( approximately 40 kb) in 50 indigenous, black South African XFS cases and 50 matched controls.

  18. This is the first study associating two SNPs of LOXL1 (rs3825942 and rs2165241) and XFS/XFG in a Spanish population, confirming findings in patients from Europe.

  19. Aortic tissue from Marfan syndrome patients and display enhanced expression of the members of the LOX family, LOX and LOX-like 1.

  20. Our meta-analysis indicates that rs1048661 had weak association with XFG/XFS; rs3825942 had strongly association with XFG/XFS; and rs2165241 had significant risk with XFG/XFS in some ethnicity.

Cow (Bovine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. The enzyme has a very stable central core containing three disulfide bonds, the lysyl tyrosyl quinone cross-link and the copper.

Mouse (Murine) Lysyl Oxidase-Like 1 (LOXL1) interaction partners

  1. findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin.

  2. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females

  3. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.

  4. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.

  5. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype

  6. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice.

  7. pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers

  8. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders

  9. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues

  10. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities.

  11. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility.

LOXL1 Protein Profile

Protein Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene names and symbols associated with Lysyl Oxidase-Like 1 Proteins (LOXL1)

  • lysyl oxidase like 1 (LOXL1)
  • lysyl oxidase like 1 (loxl1)
  • lysyl oxidase-like 1 (Loxl1)
  • lysyl oxidase-like 1 (loxl1)
  • lysyl oxidase like 1 L homeolog (loxl1.L)
  • lol protein
  • loxl protein
  • loxl-1 protein
  • oxl-1 protein
  • si:ch211-238c15.1 protein

Protein level used designations for Lysyl Oxidase-Like 1 Proteins (LOXL1)

lysyl oxidase-like 1 , lysyl oxidase homolog 1-like , lysyl oxidase homolog 1 , lysyl oxidase-like protein 1 , lysyl oxidase 2

GENE ID SPECIES
426411 Gallus gallus
706464 Macaca mulatta
100051862 Equus caballus
100124878 Xenopus (Silurana) tropicalis
100388123 Callithrix jacchus
100606325 Nomascus leucogenys
4016 Homo sapiens
281903 Bos taurus
16949 Mus musculus
315714 Rattus norvegicus
560115 Danio rerio
496210 Xenopus laevis
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