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LOXL1 encodes a member of the lysyl oxidase gene family. Additionally we are shipping LOXL1 Antibodies (81) and LOXL1 Kits (19) and many more products for this protein.
Showing 10 out of 16 products:
high lysyl oxidase (show LOX Proteins) activity is associated with ischemic hearts.
LOXL1/LOXL2 (show LOXL2 Proteins) gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.
This study focused on the relationship between lysyl oxidase (LOX (show LOX Proteins)), LOX (show LOX Proteins)-like protein 1 (LOXL1), and LOXL2 (show LOXL2 Proteins) and pulmonary emphysema pathogenesis.
These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX (show PHEX Proteins)-associated environmental and nutritional cues.
remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP (show PREP Proteins)) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP (show PREP Proteins). The role of biopsy location on LOXL1 expression requires further investigation.
In this study, we found no significant association between allele and genotype frequencies of APOE (show APOE Proteins); the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.
The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF (show PEX19 Proteins) in the South Indian population correlating with lowered LOX (show LOX Proteins) activity in the aqueous humor. The increased level of total TGF-beta (show TGFB1 Proteins) in the aqueous humor of PXF (show PEX19 Proteins) cases is possibly associated with LOX (show LOX Proteins) regulation which needs further investigation.
A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS (show FST Proteins). It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.
Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.
LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A (show DNMT3A Proteins) was concomitantly overexpressed.
The present study, for the first time, shows that the pseudoexfoliation syndrome-associated variant residues in LOXL1 influence processing of the protein, most likely by BMP-1 (show BMP1 Proteins).
findings strongly suggested that elastin (show ELN Proteins) crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin (show ELN Proteins).
LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females
Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.
There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.
loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype
Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted (show MUTED Proteins) long-term potentiation compared to LOXL +/+ mice.
pro-regions of lysyl oxidase (show LOX Proteins) and lysyl oxidase-like 1 are required for deposition onto elastic fibers
LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders
LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues
LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin (show ELN Proteins) disorganization may lead to such functional abnormalities.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
lysyl oxidase-like 1
, lysyl oxidase homolog 1-like
, lysyl oxidase homolog 1
, lysyl oxidase-like protein 1
, lysyl oxidase 2