MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) Proteins (MAD2L1)

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2L1 Antibodies (147) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAD2L1 4085 Q13257
MAD2L1 56150 Q9Z1B5
Rat MAD2L1 MAD2L1 297176  
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Top MAD2L1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 14 to 16 Days
$437.80
Details
Escherichia coli (E. coli) Human His tag Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$346.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

MAD2L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaction Partners

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. we demonstrate that the CDC20 (show CDC20 Proteins)-MAD2 complex could also be formed independently of the SAC (show ADCY10 Proteins). Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20 (show CDC20 Proteins)-MAD2 complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1 (show CCNB1 Proteins), which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.

  2. MAD2-p31 (show ATP6V1E1 Proteins)(comet) axis may serve as a potential therapeutic target for glioma.

  3. These results identify an unexpected dependency on TRIP13 (show TRIP13 Proteins) in cells overexpressing Mad2.

  4. this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma

  5. MiR (show MLXIP Proteins)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.

  6. Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.

  7. TRAP1 (show TRAP1 Proteins) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 Proteins)/TBP7 (show PSMC4 Proteins) quality control of CDK1 (show CDK1 Proteins) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  8. Thes authors show that p31 (show ATP6V1E1 Proteins)(comet) binding to the TRIP13 (show TRIP13 Proteins) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 Proteins) "pore loops", which then unfold MAD2 in the presence of ATP.

  9. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 Proteins) complex assembly

  10. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB Proteins).

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. immunofluorescence staining for mitotic arrest deficient 2-like 1 and the protein kinase (show CDK7 Proteins) TTK, components of the spindle assembly checkpoint (SAC (show ADCY10 Proteins)), suggested that this delay possibly involved SAC (show ADCY10 Proteins) activation.

  2. Mad2 (show MXI1 Proteins)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

  3. reduced MAD2 (show MXI1 Proteins) levels attenuate the apoptotic response to mis (show AMH Proteins)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  4. p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Proteins)

  5. study shows that Mad2 (show MXI1 Proteins) is a novel substrate for CCP6 (show AGBL4 Proteins) in megakaryocytes; Mad2 (show MXI1 Proteins) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  6. Exacerbating chromosome missegregation in CENP-E (show CENPE Proteins)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Proteins), Mad2 (show MXI1 Proteins), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  7. Mad2 (show MXI1 Proteins) is also repressed by p53 (show TP53 Proteins) and its upregulation is required for chromosome instability in a p53 (show TP53 Proteins) mutant tumor model

  8. Data show that Mad2 (show MXI1 Proteins) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Proteins) inhibitor in vitro.

  9. Pcid2 (show PCID2 Proteins) is essential for B cell survival through the regulation of MAD2 (show MXI1 Proteins) expression during B cell differentiation

  10. tumours that experience transient Mad2 (show MXI1 Proteins) overexpression and consequent chromosome instability recur at markedly elevated rates

MAD2L1 Protein Profile

Protein Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Gene names and symbols associated with MAD2L1

  • mitotic arrest deficient 2 like 1 (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1)
  • mitotic arrest deficient 2 like 1 (mad2l1)
  • mitotic arrest deficient 2 like 1 (Mad2l1)
  • mitotic arrest deficient 2 like 1 S homeolog (mad2l1.S)
  • AA673185 protein
  • cb408 protein
  • HSMAD2 protein
  • mad2 protein
  • MAD2L1 protein
  • XMad2 protein
  • zgc:112133 protein

Protein level used designations for MAD2L1

MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , mitotic arrest deficient, yeast, homolog-like 1 , mitotic spindle assembly checkpoint protein MAD2A , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like 1 , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 , MAD2 mitotic arrest deficient-like 1 (yeast)

GENE ID SPECIES
4085 Homo sapiens
56150 Mus musculus
337870 Bos taurus
422675 Gallus gallus
461661 Pan troglodytes
476070 Canis lupus familiaris
550434 Danio rerio
708574 Macaca mulatta
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
297176 Rattus norvegicus
380433 Xenopus laevis
100731050 Cavia porcellus
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