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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2L1 Antibodies (147) and and many more products for this protein.
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we demonstrate that the CDC20 (show CDC20 Proteins)-MAD2 complex could also be formed independently of the SAC (show ADCY10 Proteins). Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20 (show CDC20 Proteins)-MAD2 complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1 (show CCNB1 Proteins), which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.
MAD2-p31 (show ATP6V1E1 Proteins)(comet) axis may serve as a potential therapeutic target for glioma.
These results identify an unexpected dependency on TRIP13 (show TRIP13 Proteins) in cells overexpressing Mad2.
this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma
MiR (show MLXIP Proteins)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (show TRAP1 Proteins) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 Proteins)/TBP7 (show PSMC4 Proteins) quality control of CDK1 (show CDK1 Proteins) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (show ATP6V1E1 Proteins)(comet) binding to the TRIP13 (show TRIP13 Proteins) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 Proteins) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 Proteins) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB Proteins).
immunofluorescence staining for mitotic arrest deficient 2-like 1 and the protein kinase (show CDK7 Proteins) TTK, components of the spindle assembly checkpoint (SAC (show ADCY10 Proteins)), suggested that this delay possibly involved SAC (show ADCY10 Proteins) activation.
Mad2 (show MXI1 Proteins)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (show MXI1 Proteins) levels attenuate the apoptotic response to mis (show AMH Proteins)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Proteins)
study shows that Mad2 (show MXI1 Proteins) is a novel substrate for CCP6 (show AGBL4 Proteins) in megakaryocytes; Mad2 (show MXI1 Proteins) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (show CENPE Proteins)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Proteins), Mad2 (show MXI1 Proteins), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (show MXI1 Proteins) is also repressed by p53 (show TP53 Proteins) and its upregulation is required for chromosome instability in a p53 (show TP53 Proteins) mutant tumor model
Data show that Mad2 (show MXI1 Proteins) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Proteins) inhibitor in vitro.
Pcid2 (show PCID2 Proteins) is essential for B cell survival through the regulation of MAD2 (show MXI1 Proteins) expression during B cell differentiation
tumours that experience transient Mad2 (show MXI1 Proteins) overexpression and consequent chromosome instability recur at markedly elevated rates
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)