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MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. Additionally we are shipping MAP/microtubule Affinity-Regulating Kinase 2 Antibodies (97) and MAP/microtubule Affinity-Regulating Kinase 2 Proteins (10) and many more products for this protein.
In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position.
In conclusion, baicalin and DDP (show TIMM8A ELISA Kits) were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP (show TIMM8A ELISA Kits) resistance. The attenuation of DDP (show TIMM8A ELISA Kits) resistance was associated with downregulation of MARK2 and p-Akt (show AKT1 ELISA Kits).
MARK2 plays a role in promoting malignant phenotypes of lung cancer.
Phosphorylation of RNF41 (show RNF41 ELISA Kits) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.
induces asymmetric inheritance of plasma membrane domains via LGN (show GPSM2 ELISA Kits)-dependent mitotic spindle orientation in proliferating hepatocytes
Perturbation of PAR1b and SHP2 (show PTPN11 ELISA Kits) by CagA (show S100A8 ELISA Kits) underlies the oncogenic potential of CagA (show S100A8 ELISA Kits).
The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.
Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN (show GPSM2 ELISA Kits)-NuMA (show NUMA1 ELISA Kits) to yield the distinct epithelial division phenotypes.
automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3 (show F2RL2 ELISA Kits).
These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization.
data suggest ectopic PAR1 (show F2R ELISA Kits) expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR (show AFG3L2 ELISA Kits) antagonists as anti-platelet drugs
a model whereby MARK2 negatively regulates insulin (show INS ELISA Kits) sensitivity in peripheral tissue through inhibition of KSR1 (show KSR1 ELISA Kits)
ROCK1 (show ROCK1 ELISA Kits)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.
PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (show SRCIN1 ELISA Kits) in dendritic spines.
Par-1b is a regulator of glucose metabolism and adiposity in the whole animal
Interaction of MARK2 with CaMKI (show CAMK1 ELISA Kits) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.
Akt (show AKT1 ELISA Kits) enhances the activity of PAR1 (show F2R ELISA Kits) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (show HSP90 ELISA Kits) complex
Coreduction of MARK2 and DCX (show DCX ELISA Kits) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.
ELKL motif kinase 1
, PAR1 homolog b
, Ser/Thr protein kinase PAR-1B
, serine/threonine protein kinase EMK
, serine/threonine-protein kinase MARK2
, serine/threonine kinase