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MXD4 is a member of the MAD gene family .
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The E3 ligase activity of c-IAP1 (show BIRC2 Proteins) was not required for downregulation of Mad4 expression.
regulation by a transcriptional repressor complex that contains Miz-1 (show ZBTB17 Proteins) and c-Myc (show MYC Proteins)
Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells.
replicative senescence-specific factors may block c-Myc (show MYC Proteins) inhibition of Miz-1 (show ZBTB17 Proteins) activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc (show MYC Proteins) target genes
during embryonic hematopoietic differentiation Mxd4 is an important player in the regulation of blood progenitor proliferation, and downregulation of its expression might be required for a proliferative burst preceding lineage specification.
Mxd4 and Mnt upregulation following OX40 (show TNFRSF4 Proteins) engagement most likely increases T-cell survival
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
, class C basic helix-loop-helix protein 12
, max dimerization protein 4
, max dimerizer 4
, max-associated protein 4
, max-interacting transcriptional repressor MAD4
, MAX dimerization protein 4
, basic helix-loop-helix transcription factor XMad4-236
, putative basic helix-loop-helix transcription factor variant 3