Protein Summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Gene names and symbols associated with HLA-G

• major histocompatibility complex, class I, G (HLA-G) antibody

• MHC-G antibody

Protein level used designations for HLA-G

HLA G antigen , HLA class I histocompatibility antigen, alpha chain G , HLA class I molecule , HLA-G histocompatibility antigen, class I, G , MHC class I antigen G , b2 microglobulin