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plays a role in the processing of asparagine-linked oligosaccharides. Additionally we are shipping and and many more products for this protein.
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MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes
Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling.
MAN2C1 binds PTEN thereby inhibiting its phosphatidylinositol 3,4,5 triphosphate phosphatase activity
MAN2C1 methylation levels modify cumulative traumatic burden on risk of post traumatic stress disorder
regulation of Man2C1 expression is essential for maintaining efficient protein N-glycosylation
Reduced antibody response to BSA was observed in transgenic mice, suggesting that specific antibody response to tumor antigens might be suppressed by hMan2c1 transgene.
plays an important role in preventing oncosis-like death in BJAB cells
Results suggest that inhibition of alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat T cells.
Inhibition of MAN2C1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis.
These findings confirm the key role played by Man2c1 in the catabolism of free oligosaccharides.
Comparison of the mouse genomic sequence with the cDNA sequence revealed the presence of 25 introns within the cytosolic alpha-mannosidase gene. The gene spans 11.5 kb from the major transcription initiation site to the RNA cleavage site.
plays a role in the processing of asparagine-linked oligosaccharides
, mannosidase, alpha, class 2C, member 1
, alpha-mannosidase 2C1-like
, alpha mannosidase 6A8B
, alpha-D-mannoside mannohydrolase
, mannosidase, alpha 6A8
, mannosidase, alpha A, cytoplasmic
, cytosolic alpha-D-mannosidase