anti-Maternal Embryonic Leucine Zipper Kinase (MELK) Antibodies

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Additionally we are shipping MELK Kits (23) and MELK Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MELK 9833 Q14680
MELK 17279 Q61846
MELK 362510  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-MELK Antibodies at antibodies-online.com

Showing 10 out of 144 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-MELK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184576 (0.1µg/ml) staining of human testes lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of MCF-7 cells using MELK mouse mAb (green) and negative control (red) . 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of MELK staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MELK staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using MELK Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IF, IHC (p) 100 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB The anti-MRLK Pab (ABIN391223) is used in Western blot to detect MRLK in mouse brain tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB The anti-MELK Pab (ABIN391224) is used in Western blot to detect MKEL in HEPG2 tissue lysate 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details

MELK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, ,
,
, , , , , , , , , , , , , , , , , , ,
Mouse (Murine) , ,
,

, , , , , , , , , , , , ,
Rat (Rattus) , ,


, , , , , , , , , , , , ,

Top referenced anti-MELK Antibodies

  1. Human Monoclonal MELK Primary Antibody for ICC, FACS - ABIN969538 : Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. in Neuro-oncology 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MELK Primary Antibody for ELISA, WB - ABIN263108 : Nagase, Seki, Ishikawa, Tanaka, Nomura: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. in DNA research : an international journal for rapid publication of reports on genes and genomes 1996 (PubMed)

  3. Human Polyclonal MELK Primary Antibody for - ABIN2017585 : Hu, Ru, Xiao, Chaturbedi, Hoa, Tian, Zhang, Ke, Yan, Nelson, Li, Gramer, Yu, Siegel, Zhang, Jia, Jadus, Limoli, Linskey, Xing, Zhou: Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. in PLoS ONE 2013 (PubMed)

  4. Human Polyclonal MELK Primary Antibody for WB - ABIN2475560 : Niesler, Myburgh, Moore: The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis. in Experimental physiology 2007 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MELK Interaction Partners

Human Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Synthesis of MCL1 (show MCL1 Antibodies), an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling.

  2. Inhibition of MELK (genetically and pharmacologically) induces radiation sensitivity.

  3. MELK is a host factor required for optimal uncoating of the HIV-1 core to promote viral cDNA synthesis.

  4. Here, the authors report that mutagenizing MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six other cancer types. Cells that harbor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent growth.

  5. MELK-inhibitor has a role in triple-negative breast cancer cells demonstrating context-dependent response with p53 (show TP53 Antibodies) as a key determinant

  6. MELK is an oncogenic kinase involved in the pathogenesis and recurrence of hepatocellular carcinoma.

  7. Inhibition or depletion of MELK reduced cell proliferation and anchorage-dependent and -independent growth in various ovarian cancer cell lines through a G2/M cell cycle arrest, eventually resulting in apoptosis.

  8. Report IL11RA (show IL11RA Antibodies) and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas.

  9. MELK expression in hepatocellular carcinoma is extremely intense compared to its expression reported in other types of cancer and could be a promising effective tumor marker of HCC (show FAM126A Antibodies).

  10. targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold

Mouse (Murine) Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. MELK promotes cell migration and invasion via the FAK (show PTK2 Antibodies)/Paxillin (show PXN Antibodies) pathway, and plays an important role in the occurrence and development of gastric cancer.

  2. Phosphorylation of the activation loop of MPK38 induces its movement resulting in kinase activation.

  3. These results indicate that Trx (show TXN Antibodies) functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1 (show MAP3K5 Antibodies)-, TGF-beta (show TGFB1 Antibodies), and p53 (show TP53 Antibodies)-mediated activity

  4. an important role for MPK38-mediated phosphorylation of PDK1 (show PDPK1 Antibodies) in the negative regulation of PDK1 (show PDPK1 Antibodies) activity.

  5. MPK38 may act as a novel regulator for promoting p53 (show TP53 Antibodies) activity through direct phosphorylation of p53 (show TP53 Antibodies) at Ser (show SIGLEC1 Antibodies)(15).

  6. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.

  7. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP (show GFAP Antibodies)-expressing progenitors to rapid amplifying progenitors in the postnatal brain.

  8. The characterization of two novel E2F (show E2F1 Antibodies) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1 (show NCAPD2 Antibodies)) and maternal embryonic leucine zipper kinase (Melk) is reported.

  9. MPK38 physically interacts with ASK1 (show MAP3K5 Antibodies) in vivo and acts as a positive upstream regulator of ASK1 (show MAP3K5 Antibodies)

Zebrafish Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.

Xenopus laevis Maternal Embryonic Leucine Zipper Kinase (MELK) interaction partners

  1. Overexpression of xMELK leads to failure of cytokinesis and impairs accumulation RhoA- a pivotal regulator of cytokinesis.

  2. These results demonstrate the presence of a mitochondrial targeting signal at the N-terminus of the MC domain of MELK. This mitochondrial targeting signal was also functional in human HeLa cells.[MELK]

MELK Antigen Profile

Protein Summary

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis.

Gene names and symbols associated with MELK

  • maternal embryonic leucine zipper kinase (MELK) antibody
  • maternal embryonic leucine zipper kinase (melk) antibody
  • maternal embryonic leucine zipper kinase (cgd5_2270) antibody
  • maternal embryonic leucine zipper kinase (Melk) antibody
  • maternal embryonic leucine zipper kinase L homeolog (melk.L) antibody
  • AI327312 antibody
  • fb71b01 antibody
  • fe01f04 antibody
  • HPK38 antibody
  • Melk antibody
  • mKIAA0175 antibody
  • MPK38 antibody
  • wu:fb71b01 antibody
  • wu:fe01f04 antibody
  • xmelk antibody

Protein level used designations for MELK

maternal embryonic leucine zipper kinase , maternal embryonic leucine zipper kinase-like , pEg3 kinase , protein kinase Eg3 , protein kinase PK38 , tyrosine-protein kinase MELK , zMelk , Protein kinase Eg3

GENE ID SPECIES
428391 Gallus gallus
465095 Pan troglodytes
549144 Xenopus (Silurana) tropicalis
3373320 Cryptosporidium parvum Iowa II
100123808 Nasonia vitripennis
100386947 Callithrix jacchus
100586707 Nomascus leucogenys
9833 Homo sapiens
481608 Canis lupus familiaris
520088 Bos taurus
17279 Mus musculus
362510 Rattus norvegicus
30724 Danio rerio
397927 Xenopus laevis
Selected quality suppliers for anti-MELK (MELK) Antibodies
Did you look for something else?