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may play a role in bone homeostasis. Additionally we are shipping MEPE Kits (46) and and many more products for this protein.
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Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage.
Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss.
results indicated that MEPE appeared to play an important positive role in proliferation and osteogenesis differentiation of DPCs through interaction with downstream signals.
MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in Oncogenic osteomalacia patients.
Among migraineurs with aura (show AURKA Antibodies) rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (show IRX4 Antibodies) (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke.
Sclerostin (show SOST Antibodies) acts through regulation of the PHEX (show PHEX Antibodies)/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization.
MEPE may play a regulatory role in periodontal ligament cell osteogenic differentiation.
These results suggest that abnormal MEPE cleavage occurs when PHEX (show PHEX Antibodies) activity is deficient in humans.
This study demonstrates the importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide.
The patterns of expression of FGF-23 (show FGF23 Antibodies), MEPE, and DMP1 (show DMP1 Antibodies) differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions.
Mepe(-/-) molars exhibited increased thickness of predentin, dentin, and enamel over controls and decreased gene expression of Enam (show ENAM Antibodies), Bsp (show KLK6 Antibodies), Dmp1 (show DMP1 Antibodies), Dspp (show DSPP Antibodies), and Opn (show SPP1 Antibodies) by RT-PCR.
An in situ hybridization study of perlecan (show HSPG2 Antibodies), DMP1 (show DMP1 Antibodies), and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
MEPE is an important regulator of growth plate chondrocyte matrix mineralization through its cleavage to an ASARM peptide.
The temporal-spatial specific pattern and unique co-localization of Dspp (show DSPP Antibodies), Mepe, Mimecan (show OGN Antibodies) and Versican (show Vcan Antibodies) suggest they play complementary roles during odontogenesis.
Wnt3a (show WNT3A Antibodies) stimulates Mepe transcription directly by a canonical Wnt (show WNT2 Antibodies) signaling pathway through beta-catenin (show CTNNB1 Antibodies) and Lef-1 (show LEF1 Antibodies) and indirectly through the activation of a Bmp-2 (show BMP2 Antibodies) autocrine loop.
MEPE might be an important signaling molecule involved in the regulation of osteoblast and osteoclast activity during bone remodeling.
the C-terminal fragment of MEPE containing an RGD sequence, cleaved in odontoblasts, appeared to be the active form of MEPE, which may play important roles in dentinogenesis and pulpal homeostasis by keeping the odontoblasts in immature condition.
MEPE may be involved in the pathogenesis defective mineralization due to Phex (show PHEX Antibodies) deficiency in X-linked hypophosphatemia (XLH (show PHEX Antibodies)) and the Hyp (show PHEX Antibodies)-mouse.
Mepe appears to play a role in both long bone regeneration and the latter stages of skeletogenesis.
degradation of MEPE and DMP-1 (show DMP1 Antibodies) and release of ASARM peptides are chiefly responsible for the HYP (show PHEX Antibodies) mineralization defect and changes in osteoblast-osteoclast differentiation.
may play a role in bone homeostasis
matrix extracellular phosphoglycoprotein
, matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
, matrix, extracellular phosphoglycoprotein with ASARM motif (bone)-like
, matrix extracellular phosphoglycoprotein-like
, osteoblast/osteocyte factor 45
, matrix extracellular phosphoglycoprotein with ASARM motif (bone)
, ovocleidin-116 protein
, matrix extracellular phosphoglycoprotein with ASARM motif