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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP15 Antibodies (143) and MMP15 Kits (19) and many more products for this protein.
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Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 (show MMP14 Proteins) and MMP15 in regulating mammary gland adipocyte differentiation. Whereas MMP14 (show MMP14 Proteins) promotes the generation of white fat depots crucial for energy storage, MMP15 differentially controls the formation of thermogenic brown fat.
Data indicate that Snai1 (show SNAI1 Proteins) is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
TCF-4 (show TCF4 Proteins) is a co-activator of NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells
In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients.
our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis
HLA-G (show HLAG Proteins) expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.
MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin (show ENG Proteins) to produce soluble endoglin (show ENG Proteins).
MMP-15 and MMP-19 (show MMP19 Proteins) are upregulated during colorectal tumorigenesis
Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha (show HIF1A Proteins) under hypoxia.
The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues.
MMP2 (show MMP2 Proteins) activity is associated with an increase in MT2-MMP expression and with lymph node metastasis.
These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP (show MMP14 Proteins) independently of MMP-2 (show MMP2 Proteins) and MT1-MMP (show MMP14 Proteins).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
, MT-MMP 2
, Membrane type 2-MMP
, matrix metalloproteinase 15
, matrix metalloproteinase-15
, membrane-type matrix metalloproteinase 2
, membrane-type-2 matrix metalloproteinase
, matrix metalloproteinase 15 (membrane-inserted)