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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
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Human Polyclonal MMP26 Primary Antibody for WB - ABIN1881547
Liu, Cao, Li, Wu, Wang: GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts. in Reproductive biology and endocrinology : RB&E 2010
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The luciferase report assay demonstrated that MMP26 is a target gene of miR (show MLXIP Antibodies)-125b. And the expression profile of MMP26 showed an inverse relationship with miR (show MLXIP Antibodies)-125b in vivo and in vitro.
MMP26+CXCR4 (show CXCR4 Antibodies)+ cells may be circulating tumor cells in hepatocellular carcinoma.
We found that only inhibition of JNK (show MAPK8 Antibodies) significantly decreased the activation of MMP26 in response to FGF1 (show FGF1 Antibodies) stimulation, suggesting that activation of FGFR1 (show FGFR1 Antibodies) signaling may activate JNK (show MAPK8 Antibodies) to activate MMP26 in non-small-cell lung cancer
Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness.
The binding of MMP-26 to GDF15 (show GDF15 Antibodies) was responsible for the processing and maturation of pro-GDF15 (show GDF15 Antibodies), and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15 (show GDF15 Antibodies).
matrilysin-2 was an independent prognostic marker for patients with colorectal cancer
These results demonstrate that the HOXA10 (show HOXA10 Antibodies)-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation.
The MMP-26 promoter region contains a putative ER response element.
expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF (show CSF2 Antibodies) dependent tumor invasion.
Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (show TGFB1 Antibodies) (p=0.01) in more degenerated discs vs. healthier discs.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.
, matrilysin 2
, matrix metalloproteinase 26
, matrix metalloproteinase-26