anti-Matrix Metalloproteinase 20 (MMP20) Antibodies

Human Matrix Metalloproteinase 20 (MMP20) interaction partners

1. The polymorphisms in MMP2, MMP9 and MMP20 genes were not statistically associated with human dental fluorosis.

2. The levels of MMP20 silencing-induced downregulation differed amongst CSC markers, with ABCG2 and CD44 showing more pronounced downregulations.

3. common variants at 11q22.2 within MMP20 associate with neuroblastoma cases harboring 11q deletion (rs10895322)

4. The article data showed that MMP20 rs1784418 C>T (Matrix metalloproteinase 20) appears to protect against dental caries, but its effects are likely to be more marked in certain populations.

5. DSPP-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.

6. Levels of matrix metalloproteinases MMP-19 and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC).

7. The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts.

8. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD.

9. Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.

10. expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues

11. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.

12. Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.

13. mineralized content slightly decreased; magnesium substituting for calcium in crystal. anomalies affected enamel with minimal interrod enamel; apatite crystals perpendicular to enamel prisms, suggesting possible new role for MMP20 in enamel formation.

14. amelogenesis imperfecta-causing mutations were identified in three of the probands: 2)a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p.His204Arg) that substituted arginine for histidine.

15. Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits.

16. hypocalcified amelogenesis imperfecta, Witkop type III, was unrelated to previously described mutations in the ENAM or MMP-20 genes

17. MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.

18. Associations between tooth agenesis and MMP1 (p=0.007), and MMP20 (p=0.03) were found in Brazilian families. MMP20 continued to be associated with tooth agenesis (p=0.01). Mmp20 was not expressed during the initial stages of tooth development.

19. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors.

20. A mutation in the MMP-20 gene has been identified and associated with amelogenesis imperfecta.

Xenopus laevis Matrix Metalloproteinase 20 (MMP20) interaction partners

1. MMP20 in a common ancestor of tetrapods might have been recruited for the processing of AMEL and conserved over 350 million years of evolution.

Pig (Porcine) Matrix Metalloproteinase 20 (MMP20) interaction partners

1. MMP-20 is the enzyme that processes ameloblastin during the secretory stage of amelogenesis

2. MMP-20 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis

Mouse (Murine) Matrix Metalloproteinase 20 (MMP20) interaction partners

1. increased cadherin cleavage by transgenic MMP20 in the wild type background releases excess beta-catenin, which translocates to ameloblast nuclei to promote cell migration/invasion. Therefore, MMP20 plays a role in normal ameloblast migration through tightly controlled Wnt signaling and MMP20 overexpression disrupts this process.

2. MMP-20 action guides the growth morphology of the forming hydroxyapatite crystals and enhances their crystallinity.

3. Matrix metalloproteinase-20 over-expression is detrimental to enamel development

4. MMP20 cleaves extracellular domains of cadherin adherens junction proteins, both E- and N-cadherin transcripts are expressed at significantly higher levels in Mmp20 null mice; in Mmp20 ablated mice N-cadherin expression persists during maturation stage

5. enamel of M180Tg/AmelxKO mice was thinner than WT, it had similar mechanical properties and decussating enamel prisms, which were abolished by the loss of MMP20 in the M180Tg/DKO mice.

6. required for ameloblast cell movement necessary to form the decussating enamel rod patterns, for the prevention of ectopic mineral formation, and to maintain a functional dentin-enamel junction

7. MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s).

8. Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.

9. Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM.

10. expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins

11. enamelysin activity is essential for proper enamel development in mice

12. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors.

13. Analyses of amelogenin mRNA between control and Mmp20(-/-)mice revealed no differences in the splicing pattern.

14. The secretory-stage enamel organic extracellular matrix of Mmp20-/- mice showed a significant decrease in optical retardation as compared with Mmp20+/+ and Mmp20+/- mice (p=0.0000).

15. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated.