anti-Matrix Metalloproteinase 20 (MMP20) Antibodies

Human Matrix Metalloproteinase 20 (MMP20) interaction partners

1. common variants at 11q22.2 within MMP20 associate with neuroblastoma (show ARHGEF16 Antibodies) cases harboring 11q deletion (rs10895322)

2. The article data showed that MMP20 rs1784418 C>T (Matrix metalloproteinase 20) appears to protect against dental caries, but its effects are likely to be more marked in certain populations.

3. DSPP (show DSPP Antibodies)-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.

4. Levels of matrix metalloproteinases MMP-19 (show MMP19 Antibodies) and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC).

5. The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts.

6. The growth of choroidal neovascularization in AMD (show AMD1 Antibodies) would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2 (show ARMS2 Antibodies)/HTRA1 (show HTRA1 Antibodies), a well-known susceptibility gene for AMD (show AMD1 Antibodies).

7. Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.

8. expression of MMP-20 and co-expression and potential interaction with DSPP (show DSPP Antibodies) in human major salivary gland tissues

9. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.

10. Polymorphisms of MMP7 (show MMP7 Antibodies) and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.

Xenopus laevis Matrix Metalloproteinase 20 (MMP20) interaction partners

1. MMP20 in a common ancestor of tetrapods might have been recruited for the processing of AMEL (show AMELX Antibodies) and conserved over 350 million years of evolution.

Pig (Porcine) Matrix Metalloproteinase 20 (MMP20) interaction partners

1. MMP-20 is the enzyme that processes ameloblastin (show AMBN Antibodies) during the secretory stage of amelogenesis

2. MMP-20 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis

Mouse (Murine) Matrix Metalloproteinase 20 (MMP20) interaction partners

1. increased cadherin cleavage by transgenic MMP20 in the wild type background releases excess beta-catenin (show CTNNB1 Antibodies), which translocates to ameloblast nuclei to promote cell migration/invasion. Therefore, MMP20 plays a role in normal ameloblast migration through tightly controlled Wnt (show WNT2 Antibodies) signaling and MMP20 overexpression disrupts this process.

2. MMP-20 action guides the growth morphology of the forming hydroxyapatite crystals and enhances their crystallinity.

3. Matrix metalloproteinase-20 over-expression is detrimental to enamel development

4. MMP20 cleaves extracellular domains of cadherin adherens junction proteins, both E- and N-cadherin (show CDH2 Antibodies) transcripts are expressed at significantly higher levels in Mmp20 null mice; in Mmp20 ablated mice N-cadherin (show CDH2 Antibodies) expression persists during maturation stage

5. enamel of M180Tg/AmelxKO mice was thinner than WT, it had similar mechanical properties and decussating enamel prisms, which were abolished by the loss of MMP20 in the M180Tg/DKO mice.

6. MMP20 may influence ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s).

7. Effect of kallikrein 4 (show KLK4 Antibodies) loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.

8. Runx2 (show RUNX2 Antibodies) regulates the expression of ODAM (show ODAM Antibodies) and nuclear ODAM (show ODAM Antibodies) serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM (show ODAM Antibodies).

9. expression of MMP-20 correlates with the stage-associated changes in the digestion of enamel proteins

10. enamelysin activity is essential for proper enamel development in mice