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MPP3 product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs).
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a central role of CADM1 (show CADM1 Proteins) in stabilizing the complex with 4.1B (show EPB41L3 Proteins) and MPP3
MPP3 and Dlg (show DLG4 Proteins), membrane-associated guanylate kinase (show GUK1 Proteins) homologs (MAGuK) proteins, connect CADM1 (show CADM1 Proteins) with p85 of PI3K (show PIK3CA Proteins) by forming a multi-protein complex at the periphery of cells.
MPP3 plays an important role in hepatocellular carcinoma metastasis by promoting cell migration and invasion via up-regulating MMP1 (show MMP1 Proteins)
Data suggested that epigenetic inactivation of MPP3 frequently occurred during the development of colorectal cancer and might also be a potential biomarker for molecular classification of colorectal cancer patients.
TSLC1 (show CADM1 Proteins) strongly inhibits the growth of HepG2 cells in vitro and induces apoptosis.
MPP3, a human homologue of a Drosophila tumor suppressor gene (Discs large (show DLG4 Proteins)), associates with TSCL1, a tumor suppressor gene.
These data implicate a role for MPP3 in photoreceptor polarity and, by association with MPP5 (show MPP5 Proteins), pinpoint MPP3 as a functional candidate gene for inherited retinopathies.
The data of this studysuggested that MPP3 is required for maintaining proper levels of PALS1 (show MPP5 Proteins) at the subapical region, and indicate that the MPP3 gene is a candidate modulator of the Crumbs complex.
This study show that MPP3 is required for maintenance of the apical protein complex and adherens junctions and for stratification and proper migration of neurons during the development of the cortex.
This indicates that, overall, interaction of 5-HT(2C) receptors with PDZ proteins inhibits receptor desensitization in cortical neurons.
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein.
MAGUK p55 subfamily member 3
, discs large homolog 3
, discs, large homolog 3
, membrane protein palmitoylated 3
, Mpp3 membrane protein, palmitoylated 3
, protein Dlgh3