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MS4A3 encodes a member of the membrane-spanning 4A gene family. Additionally we are shipping MS4A3 Antibodies (42) and many more products for this protein.
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These results suggest that cell surface expression of MS4A3 is useful to distinguish granulocyte/macrophage lineage-committed progenitors from other lineage-related ones in early human hematopoiesis. In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis.
Murine HTm4 is predominantly a hematopoietic protein and highly expressed in the developing and adult murine nervous system.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (show MPO Proteins), CEACAM8, CRISP3 (show CRISP3 Proteins), MS4A3, CEACAM6, HEMGN, and MMP8 (show MMP8 Proteins)
Our data reveal MS4A3 as a novel direct target of EVI1 (show MECOM Proteins) in human myeloid cells, and show that its repression plays a role in EVI1 (show MECOM Proteins) mediated tumor aggressiveness.
The C-terminal domain is important for the function of HTm4 in cell cycle regulation.
High HTm4 is associated with neoplasms.
HTm4 binding to KAP.Cdk2.cyclin A (show CCNA2 Proteins) complex enhances the phosphatase activity of KAP (show CDKN3 Proteins), dissociates cyclin A (show CCNA2 Proteins), and facilitates KAP (show CDKN3 Proteins) dephosphorylation of Cdk2 (show CDK2 Proteins)
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants\; however, not all variants have been fully described.
membrane-spanning 4-domains, subfamily A, member 3
, haematopoietic cell-specific transmembrane-4
, hematopoietic-specific transmembrane protein 4
, membrane-spanning 4-domains subfamily A member 3
, CD20 antigen homolog
, CD20 antigen-like protein
, IgE receptor beta chain
, IgE receptor beta subunit
, hematopoietic cell 4 transmembrane protein