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MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Additionally we are shipping MACC1 Kits (11) and MACC1 Proteins (4) and many more products for this protein.
Showing 10 out of 43 products:
Human Polyclonal MACC1 Primary Antibody for IF (p), IHC (p) - ABIN706526
Sun, Li, Dai, Tan, Zhao, Li, Wang: Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. in Molecular medicine reports 2015
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Human Polyclonal MACC1 Primary Antibody for IHC, IHC (p) - ABIN4332277
Ge, Meng, Zhou, Zhang, Ding: Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer. in International journal of clinical and experimental medicine 2015
Show all 2 Pubmed References
Human Polyclonal MACC1 Primary Antibody for IHC, IHC (p) - ABIN4332275
Hagemann, Fuchs, Monoranu, Herrmann, Smith, Hohmann, Grabiec, Kessler, Dehghani, Löhr, Ernestus, Vince, Stein: Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. in Neuro-oncology 2013
Human Polyclonal MACC1 Primary Antibody for ELISA, IHC - ABIN5582886
Liu, Pan, Guo, Wu, Guo, Peng, Wu, Zuo: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. in Journal of hematology & oncology 2016
these findings highlight the pivotal role of miR (show MLXIP Antibodies)-218 in various aspects of MACC1 expression regulation and MACC1-mediated colorectal cancer progression
MACC1-induced tumor progression in colorectal cancer acts, at least in part, via the newly discovered MACC1/Nanog (show NANOG Antibodies)/Oct4 (show POU5F1 Antibodies) axis.
Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2 (show PDLIM2 Antibodies), MACC1, NTN4, and GNB2L1 (show GNB2L1 Antibodies).
H19 (show NCKAP1 Antibodies) may regulate non-small cell lung cancer (NSCLC) metastasis through modulating cellular signaling pathway proteins related to cell proliferation and cell adhesion, including MACC1, EGFR (show EGFR Antibodies), beta-catenin (show CTNNB1 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies).
Metastasis-associated in colon cancer 1 is expressed at early stages of colorectal oncogenesis within the affected colonic tissue in colorectal cancer patient cohort.
MACC1 is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC (show CALR Antibodies)). Data suggest that some small molecules with antineoplastic activity inhibit MACC1 transcription in CRC (show CALR Antibodies) and prevent liver metastasis in CRC (show CALR Antibodies); lovastatin and rottlerin are the antineoplastic agents used here.
MACC1 regulates Fas (show FAS Antibodies) mediated apoptosis through STAT1 (show STAT1 Antibodies)/3 - Mcl-1 (show MCL1 Antibodies) signaling in solid cancers.
High expression of MACC1 is associated with non-small cell lung cancer.
MACC1 down-regulation suppresses endometrial carcinoma cell proliferation.
SPON2 (show SPON2 Antibodies) is a transcriptional target of the metastasis gene MACC1. SPON2 (show SPON2 Antibodies) induces cell motility in vitro and CRC (show CALR Antibodies) metastasis in mice. In patients, SPON2 (show SPON2 Antibodies) serves as prognostic indicator for CRC (show CALR Antibodies) metastasis and survival, and might represent a promising target for therapeutic approaches.
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009
SH3 domain-containing protein 7a5
, metastasis-associated in colon cancer protein 1
, putative binding protein 7a5