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The protein encoded by MSRB3 catalyzes the reduction of methionine sulfoxide to methionine.
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Human Polyclonal MSRB3 Primary Antibody for IHC, IHC (p) - ABIN4335886
Ahmed, Yousaf, Lee, Khan, Lee, Lee, Husnain, Rehman, Bonneux, Ansar, Ahmad, Leal, Gladyshev, Belyantseva, Van Camp, Riazuddin, Friedman, Riazuddin: Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. in American journal of human genetics 2011
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This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease.
Oncogene (show RAB1A Antibodies) induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 (show ZEB1 Antibodies) and MSRB3. The prevention of oncogene (show RAB1A Antibodies)-induced DNA damage precludes induction of the oncosuppressive p53 (show TP53 Antibodies)-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.
The data suggest that MsrB3 attenuates HO-1 (show HMOX1 Antibodies) induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 (show GABPA Antibodies) activation.
MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway.
Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status.
MsrB3 deficiency activates the cell cycle inhibitors p21 (show CDKN1A Antibodies) and p27 (show PAK2 Antibodies).
DNA methylation (show HELLS Antibodies) shows genome-wide association of NFIX (show MLZE Antibodies), RAPGEF2 (show RAPGEF2 Antibodies) and MSRB3 with gestational age at birth.
these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis.
Taken together, these data provide evidence that the ER type of MsrB (show MSRB2 Antibodies), MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging.
Results identified an antimicrobial peptide (show CAMP Antibodies) from the human methionine sulfoxide reductase B3 protein.
results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy
data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency.
MsrB3 deficiency activates the cell cycle inhibitors p21 (show D4S234E Antibodies) and p27 (show CDKN1B Antibodies).
data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB (show MSRB2 Antibodies) isozymes. [MsrB3]
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
methionine-R-sulfoxide reductase B3
, methionine-R-sulfoxide reductase B3, mitochondrial
, Methionine-R-sulfoxide reductase B3, mitochondrial