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MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. Additionally we are shipping Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Proteins (9) and Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Kits (7) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal MTHFD2 Primary Antibody for ICC, IF - ABIN443140
Moran, Trusk, Pry, Paz, Sidransky, Bacus: KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells. in Molecular cancer therapeutics 2014
Cow (Bovine) Polyclonal MTHFD2 Primary Antibody for WB - ABIN2782446
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
Data suggest that Ad4BP (show NR5A1 Antibodies) plays role in regulation of intracellular NADPH (show FDXR Antibodies) concentration via transcription of Me1 (show ME1 Antibodies) and Mthfd2 genes in adrenocortical cells. (Ad4BP (show NR5A1 Antibodies) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Antibodies); Me1 (show ME1 Antibodies) = malic enzyme 1 (show ME1 Antibodies); Mthfd2 = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
A mutation in methylenetetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)) gene, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome.
miR (show MLXIP Antibodies)-92a inhibits proliferation and induces apoptosis by directly regulating MTHFD2 expression in AML (show RUNX1 Antibodies).
metabolic alterations in MCF7 cells observed as a consequence of MTHFD2 suppression
crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.
Mechanistically, MYC (show MYC Antibodies) regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle.
siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC (show FAM126A Antibodies), and is associated with poor prognosis and cellular features connected to metastatic disease.
These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.
The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2.
Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments.
Data indicate that the reduced vimentin (show VIM Antibodies) expression in response to EPHB4 (show EPHB4 Antibodies), WIPF2 (show WIPF2 Antibodies) and MTHFD2 silencing was observed at mRNA and protein levels.
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
, methylene tetrahydrofolate dehydrogenase 2
, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
, methylenetetrahydrofolate dehydrogenase 2
, NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
, methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
, methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase