Microtubule-Actin Crosslinking Factor 1 Proteins (MACF1)

The protein encoded by MACF1 belongs to the plakin family of cytoskeletal linker proteins. Additionally we are shipping MACF1 Antibodies (18) and MACF1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MACF1 23499 Q9UPN3
MACF1 11426  
MACF1 362587  
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Top MACF1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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MACF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)
Rat (Rattus)

More Proteins for Microtubule-Actin Crosslinking Factor 1 (MACF1) Interaction Partners

Zebrafish Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. We propose that Macf1a does not function via its canonical mechanism of linking two cytoskeletal systems together in dissociating the Bb. Instead our results suggest that Macf1a functions by linking one cytoskeletal system, cortical actin, to another structure, the Bb, where Macf1a is localized.

  2. Macf1 regulates the balbiani body and the polarity of oocyte.

Human Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer.

  2. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends.

  3. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments.

  4. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas

  5. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases.

  6. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability

  7. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2 (show ERBB2 Proteins).

  8. p230, through its interaction with MACF1, provides the molecular link for transport of GPI (show GNPDA1 Proteins)-anchored proteins along the microtubule and actin cytoskeleton from the TGN (show TG Proteins) to the cell periphery.

Mouse (Murine) Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells.

  2. Data show that microtubule actin crosslinking factor 1 (MACF1) determines neuronal positioning by regulating microtubule dynamics and mediating glycogen synthase kinase 3 (show GSK3a Proteins) (GSK-3) signaling during brain development.

  3. data identify for the first time, a role for MACF1 in cardiomyocyte microtubule distribution and in adaptation to hemodynamic overload

  4. Studied ACF7 and paracellular permeability, by conditional knock out of ACF7 in the intestinal mucosa of mice. Findings indicated that ACF7 deficiency resulted in significant interstitial proliferation and columnar epithelial cell rearrangement.

  5. ACF7 is a linker protein (show LAT Proteins) that helps to shape the cytoskeleton of the hair cell during early hair-bundle genesis.

  6. Study identified a link between GSK3beta and ACF7 and further reveal the in vivo relevance of this connection in polarized locomotion of skin stem cells upon injury.

  7. Our data suggest a critical role for MACF1 in neuronal migration that is dependent on its ability to interact with both microfilaments and microtubules.

  8. In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites.

  9. a new role of MACF1 in the Wnt (show WNT2 Proteins) signaling pathway, MACF1 was highly expressed in neuronal tissues and the foregut of embryonic day 8.5 (E8.5) embryos and the head fold and primitive streak of E7.5 embryos.

  10. ACF7 deficiency compromises the targeting of microtubules along F-actin to focal adhesions (FAs), stabilizes FA-actin networks, and impairs epidermal migration.

MACF1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with MACF1

  • microtubule-actin crosslinking factor 1 (MACF1)
  • microtubule-actin crosslinking factor 1a (macf1a)
  • microtubule-actin crosslinking factor 1 (macf1)
  • microtubule-actin cross-linking factor 1 (LOC100175356)
  • dual specificity protein kinase CLK3 (LOC100514848)
  • microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (LOC100550622)
  • microtubule-actin crosslinking factor 1 (Macf1)
  • ABP620 protein
  • Acf7 protein
  • Aclp7 protein
  • DKFZp469K2016 protein
  • fc46g01 protein
  • MACF protein
  • MACF1 protein
  • mKIAA0465 protein
  • OFC4 protein
  • R74989 protein
  • si:rp71-45k5.7 protein
  • wu:fc46g01 protein

Protein level used designations for MACF1

microtubule-actin crosslinking factor 1 , microfilament and actin filament cross-linker protein , actin-crosslinking protein , magellan , mgn , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 , Microtubule-actin cross-linking factor 1-like , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5-like , 620 kDa actin binding protein , actin cross-linking family protein 7 , macrophin 1 , microtubule-actin cross-linking factor 1 , trabeculin-alpha , actin cross-linking family 7 , actin-crosslinking protein 7 , trabeculin alpha

GENE ID SPECIES
419671 Gallus gallus
456778 Pan troglodytes
475321 Canis lupus familiaris
506730 Bos taurus
562190 Danio rerio
100025003 Monodelphis domestica
100068727 Equus caballus
100127846 Xenopus (Silurana) tropicalis
100173160 Pongo abelii
100175356 Ciona intestinalis
100341624 Oryctolagus cuniculus
100479117 Ailuropoda melanoleuca
100514848 Sus scrofa
100550622 Meleagris gallopavo
23499 Homo sapiens
11426 Mus musculus
362587 Rattus norvegicus
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