Milk Fat Globule-EGF Factor 8 Protein Proteins (MFGE8)

involved in the O-acetylation of GD3 ganglioside sialic acid [RGD, Feb 2006].. Additionally we are shipping MFGE8 Antibodies (180) and MFGE8 Kits (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MFGE8 4240 Q08431
MFGE8 17304 P21956
MFGE8 25277 P70490
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Top MFGE8 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 14 to 16 Days
$382.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 11 Days
$341.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$221.48
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,122.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,135.00
Details

MFGE8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) , ,

Rat (Rattus) ,
,

More Proteins for Milk Fat Globule-EGF Factor 8 Protein (MFGE8) Interaction Partners

Human Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. Esophageal cancer patients with high MFG-E8 expression had worse overall survival and relapse-free survival in the subgroup with preoperative chemotherapy. The abundant MFG-E8 expression in esophageal squamous cell carcinoma might have a negative influence on the long-term survival of patients after chemotherapy by affecting T-cell regulation in the tumor microenvironment.

  2. MFGE8 polymorphisms were not associated with MetS but were related to DBP, HDL-C level, and WC in Chinese adults.

  3. This study showed for the first time that MFG-E8 expression is impaired in the endometrium of patients with endometriosis and infertility during the window of implantation.

  4. Our findings suggest that both MFGE8 and TGFbeta1 are agerelated inflammatory factors and are related to the degree of Atherosclerosis (AS). In conclusion, both MFGE8 and TGFbeta1 may serve as potential markers of the severity of AS

  5. Elevated serum MFG-E8 levels may be associated with cerebrovascular diseases or neuropsychiatric systemic lupus erythematosus.

  6. Circulating MFG-E8 levels are dramatically elevated in pregnancy, and are significantly higher in gestational diabetes mellitus than in normal pregnancy.

  7. MFG-E8 could be a potential novel prognostic marker for colorectal cancer (CRC) and overexpression of MFG-E8 might be involved in lymph node metastasis and angiogenesis of CRC.

  8. MFG-E8 levels are elevated in T2D but suppressed by increased adipose tissues, thereby allowing inflammatory factors to rise to high levels. MFG-E8 may serve as a potential biomarker for obesity and T2D in the clinical setting

  9. These findings provide a better understanding of the molecular mechanism underlying colorectal cancer progression and suggest a predictive role for MFG-E8 in colorectal cancer metastasis and prognosis

  10. Levels of MFGE8 were reduced in cirrhotic liver tissue from patients compared with controls.

  11. an efficient purification method for production of non-aggregated, full-length MFG-E8.

  12. Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.

  13. MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.

  14. After myocardial infarction, Mfge8 (and Mertk)-expressing macrophages synergistically engage the clearance of injured cardiomyocytes.

  15. Studied the therapeutic effect of rhMFG-E8 in mouse models of IBD. Treatment with rhMFG-E8 significantly attenuated colitis in both models in a dose-dependent way.

  16. MFG-E8 promotes cutaneous wound healing by enhancing angiogenesis.

  17. Lactadherin may decrease inflammation by inhibiting secretory phospholipase A2 activity on pre-apoptotic leukemia cells.

  18. promotes tumor progression in oral squamous cell carcinoma

  19. MFG-E8 had a negative association with hs-CRP and a positive association with LDL-c. The serum level of MFG-E8 was negatively associated with the severity of coronary artery stenosis and the risk of clinical events.

  20. medin adopts a predominantly beta-sheet conformation with some unstructured elements.

Cow (Bovine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism.

  2. lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication

  3. Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.

  4. The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content

  5. The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined.

  6. analysis of membrane-interactive loops of Lact-C2

  7. angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells

Mouse (Murine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. study suggests that LPS represses MFG-E8 expression and disrupts enterocyte migration via a miR-99b dependent mechanism.

  2. Mesenchymal stem cell-derived MFG-E8 might accelerate diabetic wound healing by promoting angiogenesis, the clearance of apoptotic cells, and the infiltration of M2 macrophages, and by suppressing inflammatory cytokines in wound area.

  3. MFG-E8 localized to the basal lamina of the mammary gland during involution. Basal MFG-E8 localization promoted integrin-dependent suppression of beta-casein expression.

  4. MFG-E8 reduces neutrophil migration and neutrophil extracellular traps via downregulating surface CXCR2 expression in parallel with its role in the phagocytosis of apoptotic neutrophils.

  5. Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.

  6. MFG-E8 administration was associated with decreased inflammasome activation in the kidney. Adoptive transfer of MFG-E8-stimulated macrophages reduced activation of inflammasome and tissue damage. The protective role of MFG-E8 in ureteral obstruction kidney injury is mediated through anti-inflammatory macrophage reprogramming which results in decreased inflammasome activation, preventing severe tissue damage.

  7. characterization of the mechanisms by which macrophage derived MFG-E8 regulates wound inflammation; wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis

  8. MFG-E8 acts at two levels, by increasing VEGF and ET-1 expression in mesenchymal stromal cells (MSC) and by enhancing M2 polarization of macrophages, to increase tumor angiogenesis.

  9. MFGE8 is an anti-fibrotic protein in mesenchymal stem cell secretomes that strongly inhibits TGFbeta signaling and reduces extracellular matrix deposition and liver fibrosis in mice.

  10. an efficient purification method for production of non-aggregated, full-length MFG-E8.

  11. MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.

  12. Milk fat globule-epidermal growth factor-factor VIII downregulates interleukin-17 expression in sepsis by modulating STAT3 activation.

  13. Data indicate that Sp1 and AP-1-related factors are involved in the regulation of MFG-E8 gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.

  14. MFG-E8 promotes tumor growth regardless of the presence or absence of colonic inflammation, whereas colon tumor development is initiated by MFG-E8 under inflammatory conditions.

  15. The MFG-E8 in breast milk may mask the phosphatidylserine exposed on the surface of mik fat globules(MFGs) with time after secretion and thereby suppress the membrane fusion among MFGs resulting in the enlargement of MFGs in the breast milk.

  16. data indicate that MFG-E8 controls steady-state and pathological bone turnover and may therefore represent a new target gene in the treatment of bone diseases

  17. MFG-8 is expressed in fetal hematopoietic stem cells populations, and MFG-E8 may have a role in embryonic hematopoiesis.

  18. increased TGFbeta1 expression in models of neurodegeneration might be involved in clearance of apoptotic cells via regulation of Milk fat globule-epidermal growth factor-factor 8 expression

  19. MFG-E8 may inhibit the formation of pressure ulcers induced by cutaneous I/R injury by regulating angiogenesis and inflammation

  20. results uncover a unique role of efferocytosis via MFG-E8 as a mechanism for macrophage polarization into tumor-promoting M2 cells

Pig (Porcine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The evidence suggests that lactadherin and the other F4-binding milk proteins, together with other defense components of milk, could play a role in protection of neonatal piglets against ETEC induced diarrhea.

MFGE8 Protein Profile

Protein Summary

involved in the O-acetylation of GD3 ganglioside sialic acid

Gene names and symbols associated with MFGE8

  • milk fat globule-EGF factor 8 protein (mfge8)
  • milk fat globule-EGF factor 8 protein (MFGE8)
  • milk fat globule-EGF factor 8 protein b (mfge8b)
  • milk fat globule-EGF factor 8 protein L homeolog (mfge8.L)
  • milk fat globule-EGF factor 8 protein (Mfge8)
  • AA408458 protein
  • AGS protein
  • AI325141 protein
  • BA46 protein
  • EDIL1 protein
  • HMFG protein
  • hP47 protein
  • HsT19888 protein
  • lactadherin protein
  • MFG-E8 protein
  • mfge8 protein
  • Mfgm protein
  • MFGME8 protein
  • MFGMP-E8 protein
  • MGC75581 protein
  • MGC99228 protein
  • MGC145109 protein
  • OAcGD3S protein
  • P47 protein
  • SED1 protein
  • SPAG10 protein
  • zgc:154157 protein

Protein level used designations for MFGE8

milk fat globule-EGF factor 8 protein , sperm-membrane associated protein P47 , O-acetyl disialoganglioside synthase , breast epithelial antigen BA46 , lactadherin , medin , sperm associated antigen 10 , sperm surface protein hP47 , BP47 , MFG-E8 , MFGM , MGP57/53 , PAS-6/PAS-7 glycoprotein , SED1 , components 15/16 , sperm surface protein SP47 , EGF/factor VIII , MP47 , milk fat globule glycoprotein , O-acetyl GD3 ganglioside synthase , O-acetyltransferase Milk fat glolbule membrane protein , O-acetyltransferase milk fat globule membrane protein , milk fat globule EGF factor 8 protein , pP47 protein

GENE ID SPECIES
395038 Xenopus (Silurana) tropicalis
415494 Gallus gallus
453631 Pan troglodytes
488730 Canis lupus familiaris
558580 Danio rerio
735060 Xenopus laevis
100033943 Equus caballus
100585952 Nomascus leucogenys
4240 Homo sapiens
281913 Bos taurus
17304 Mus musculus
25277 Rattus norvegicus
100861394 Capra hircus
397545 Sus scrofa
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