Milk Fat Globule-EGF Factor 8 Protein Proteins (MFGE8)

involved in the O-acetylation of GD3 ganglioside sialic acid [RGD, Feb 2006]..

list all proteins Gene Name GeneID UniProt
Human MFGE8 MFGE8 4240 Q08431
Mouse MFGE8 MFGE8 17304 P21956
Rat MFGE8 MFGE8 25277 P70490
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Top MFGE8 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,122.17
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,135.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,135.00
Details

More Proteins for Milk Fat Globule-EGF Factor 8 Protein (MFGE8) Interaction Partners

Human Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. Elevated serum MFG-E8 levels may be associated with cerebrovascular diseases or neuropsychiatric systemic lupus erythematosus.

  2. Circulating MFG-E8 levels are dramatically elevated in pregnancy, and are significantly higher in gestational diabetes mellitus than in normal pregnancy.

  3. MFG-E8 could be a potential novel prognostic marker for colorectal cancer (CRC (show CALR Proteins)) and overexpression of MFG-E8 might be involved in lymph node metastasis and angiogenesis of CRC (show CALR Proteins).

  4. MFG-E8 levels are elevated in T2D but suppressed by increased adipose tissues, thereby allowing inflammatory factors to rise to high levels. MFG-E8 may serve as a potential biomarker for obesity and T2D in the clinical setting

  5. These findings provide a better understanding of the molecular mechanism underlying colorectal cancer progression and suggest a predictive role for MFG-E8 in colorectal cancer metastasis and prognosis

  6. Levels of MFGE8 were reduced in cirrhotic liver tissue from patients compared with controls.

  7. an efficient purification method for production of non-aggregated, full-length MFG-E8.

  8. Reduced serum milk fat globule-epidermal growth factor (show EGF Proteins) 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.

  9. MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.

  10. After myocardial infarction, Mfge8 (and Mertk (show MERTK Proteins))-expressing macrophages synergistically engage the clearance of injured cardiomyocytes.

Cow (Bovine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism.

  2. lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication

  3. Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.

  4. The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content

  5. The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined.

  6. angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells

Mouse (Murine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. study suggests that LPS (show TLR4 Proteins) represses MFG-E8 expression and disrupts enterocyte migration via a miR (show MLXIP Proteins)-99b dependent mechanism.

  2. Mesenchymal stem cell-derived MFG-E8 might accelerate diabetic wound healing by promoting angiogenesis, the clearance of apoptotic cells, and the infiltration of M2 macrophages, and by suppressing inflammatory cytokines in wound area.

  3. MFG-E8 localized to the basal lamina of the mammary gland during involution. Basal MFG-E8 localization promoted integrin-dependent suppression of beta-casein (show CSN2 Proteins) expression.

  4. MFG-E8 reduces neutrophil migration and neutrophil extracellular traps via downregulating surface CXCR2 (show CXCR2 Proteins) expression in parallel with its role in the phagocytosis of apoptotic neutrophils.

  5. Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.

  6. MFG-E8 administration was associated with decreased inflammasome activation in the kidney. Adoptive transfer of MFG-E8-stimulated macrophages reduced activation of inflammasome and tissue damage. The protective role of MFG-E8 in ureteral obstruction kidney injury is mediated through anti-inflammatory macrophage reprogramming which results in decreased inflammasome activation, preventing severe tissue damage.

  7. characterization of the mechanisms by which macrophage derived MFG-E8 regulates wound inflammation; wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis

  8. MFG-E8 acts at two levels, by increasing VEGF (show VEGFA Proteins) and ET-1 (show EDN1 Proteins) expression in mesenchymal stromal cells (MSC (show MSC Proteins)) and by enhancing M2 polarization of macrophages, to increase tumor angiogenesis.

  9. MFGE8 is an anti-fibrotic protein in mesenchymal stem cell secretomes that strongly inhibits TGFbeta (show TGFB1 Proteins) signaling and reduces extracellular matrix deposition and liver fibrosis in mice.

  10. an efficient purification method for production of non-aggregated, full-length MFG-E8.

Pig (Porcine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The evidence suggests that lactadherin and the other F4-binding milk proteins, together with other defense components of milk, could play a role in protection of neonatal piglets against ETEC induced diarrhea.

MFGE8 Protein Profile

Protein Summary

involved in the O-acetylation of GD3 ganglioside sialic acid

Gene names and symbols associated with MFGE8

  • milk fat globule-EGF factor 8 protein (mfge8)
  • milk fat globule-EGF factor 8 protein (MFGE8)
  • milk fat globule-EGF factor 8 protein b (mfge8b)
  • milk fat globule-EGF factor 8 protein L homeolog (mfge8.L)
  • milk fat globule-EGF factor 8 protein (Mfge8)
  • AA408458 protein
  • AGS protein
  • AI325141 protein
  • BA46 protein
  • EDIL1 protein
  • HMFG protein
  • hP47 protein
  • HsT19888 protein
  • lactadherin protein
  • MFG-E8 protein
  • mfge8 protein
  • Mfgm protein
  • MFGME8 protein
  • MFGMP-E8 protein
  • MGC75581 protein
  • MGC99228 protein
  • MGC145109 protein
  • OAcGD3S protein
  • P47 protein
  • SED1 protein
  • SPAG10 protein
  • zgc:154157 protein

Protein level used designations for MFGE8

milk fat globule-EGF factor 8 protein , sperm-membrane associated protein P47 , O-acetyl disialoganglioside synthase , breast epithelial antigen BA46 , lactadherin , medin , sperm associated antigen 10 , sperm surface protein hP47 , BP47 , MFG-E8 , MFGM , MGP57/53 , PAS-6/PAS-7 glycoprotein , SED1 , components 15/16 , sperm surface protein SP47 , EGF/factor VIII , MP47 , milk fat globule glycoprotein , O-acetyl GD3 ganglioside synthase , O-acetyltransferase Milk fat glolbule membrane protein , O-acetyltransferase milk fat globule membrane protein , milk fat globule EGF factor 8 protein , pP47 protein

GENE ID SPECIES
395038 Xenopus (Silurana) tropicalis
415494 Gallus gallus
453631 Pan troglodytes
488730 Canis lupus familiaris
558580 Danio rerio
735060 Xenopus laevis
100033943 Equus caballus
100585952 Nomascus leucogenys
4240 Homo sapiens
281913 Bos taurus
17304 Mus musculus
25277 Rattus norvegicus
100861394 Capra hircus
397545 Sus scrofa
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