Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) ELISA Kits

Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

1. TIIA triggered HGK/JNK1-dependent Jun activation and led to increased Jun recruitment to AP-1-binding site in the SESN2 promoter region.

2. miR-200c could suppress cervical cancer cell proliferation and progression via regulating MAP4K4, which might provide a new target for cervical cancer diagnosis and therapy

3. Our findings showed that 5-FU inhibited malignant behavior of human colorectal cancer (CRC) cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC

4. Results show that MAP4K4 is a target gene for the novel miR-TG. Its expression is up-regulated in papillary thyroid carcinoma (PTC) which is inversely correlated with that of miR-TG.

5. These results suggest that downregulation of miR-98-5p promotes tumor development by downregulation of MAP4K4 and inhibition of the downstream MAPK/ERK signaling

6. an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4+ T cells through MAP4K4 expression.

7. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.

8. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway.

9. these findings identify MAP4K4 as a novel MAPK/ERK pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance.

10. This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes

11. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

12. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM

13. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D.

14. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells

15. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4

16. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer.

17. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target

18. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation

19. results reveal a key target of SOX2 expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase pathways, in regulating tumor cell survival.

20. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

1. TLR4-MAP4K4 pathway can regulate retinal neovascularization.

2. Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.

3. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.

4. Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.

5. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.

6. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice.

7. These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.

8. Mice with Map4k4 deleted in Myf5-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin resistance.

9. HGK/MAP4K4 deficiency has a role in inducing TRAF2 stabilization and Th17 differentiation leading to insulin resistance

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11. microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2

12. MAP4K4 is essential for CD4+ T cell proliferation and activation in vitro through suppressing PKC-theta activation.

13. Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 in an AMPK- and mTOR-dependent but JNK-independent mechanism.

14. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation.

15. MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells.

16. These findings suggest that scorpion venom induces insulin resistance by mechanisms involving TNF-alpha-dependent Map4k4 kinase activation in the adipose tissue.

17. These data together with previous reports on extramedullary hemopoiesis in RelB-deficient mice suggest that NIK-RelB signaling may be involved in the suppression of extramedullary hemopoiesis in adult mice.

18. inhibitory effect of the NIK aly mutation on the process of osteoclast differentiation is, at least in part, closely linked to the alternative NF-kappaB signaling pathway.

19. Map4k4 negatively regulates PPARgamma post-transcriptionally, by attenuating mTOR signaling and a 4E-BP1-dependent mechanism

20. These results reveal a MAP4K4/NIK-dependent signaling pathway that potently inhibits PPARgamma-responsive gene expression

Cow (Bovine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

1. study identified single nucleotide polymorphisms at different locations of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene of cattle and several of them were significantly associated with the somatic cell score and other different milk traits