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MAP4K5 encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Additionally we are shipping Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 Antibodies (55) and many more products for this protein.
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MAP4K5 expression is decreased or lost in majority of pancreatic ductal adenocarcinoma.
TNF (show TNF Proteins) signaling leads to oligomerization, ubiquitination, and activation of GCKR (show GCKR Proteins) and activation of the SAPK (show MAPK9 Proteins) pathway in a manner that depends upon TRAF2 (show TRAF2 Proteins) polyubiquitination and oligomerization and Ubc13 (show UBE2N Proteins) function
The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Han Chinese from Shanghai.
Germinal center kinase-related enzyme (GCKR (show GCKR Proteins)) facilitates both canonical and noncanonical Wnt (show WNT2 Proteins) signaling in B lymphocytes.
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
MAPK/ERK kinase kinase kinase 5
, MEK kinase kinase 5
, MEKKK 5
, germinal center kinase-related
, kinase homologous to SPS1/STE20