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Activates the JUN N-terminal pathway (By similarity).. Additionally we are shipping Mitogen-Activated Protein Kinase Kinase Kinase MLK4 Antibodies (73) and and many more products for this protein.
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These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 binding is important for regulating MLK3 activity and MAPK signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 proteins decline via CHIP-dependent degradation.
results uncover MLK4 as an upstream regulator of NF-kappaB signaling and a potential molecular target for the MES subtype of glioblastomas
In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1) and that MEK/ERK (MAPK1) signaling is impaired in MLK4 knockout cells
MLK4 is a negative regulator of TLR4 signaling.
Activates the JUN N-terminal pathway (By similarity).
mitogen-activated protein kinase kinase kinase MLK4
, mixed lineage kinase 4
, mixed lineage kinase 4-like