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Activates the JUN N-terminal pathway (By similarity)..
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These results suggest that in the early response to stressful stimuli, MLK4beta-MLK3 (show MAP3K11 Proteins) binding is important for regulating MLK3 (show MAP3K11 Proteins) activity and MAPK (show MAPK1 Proteins) signalling, and after prolonged periods of stress exposure, MLK4beta and MLK3 (show MAP3K11 Proteins) proteins decline via CHIP-dependent degradation.
results uncover MLK4 as an upstream regulator of NF-kappaB (show NFKB1 Proteins) signaling and a potential molecular target for the MES (show ME1 Proteins) subtype of glioblastomas
In establishing the role of MLK4 in intracellular signaling, we show it directly phosphorylates MEK1 (MAP2K1 (show MAP2K1 Proteins)) and that MEK (show MAP2K1 Proteins)/ERK (MAPK1 (show MAPK1 Proteins)) signaling is impaired in MLK4 knockout cells
MLK4 is a negative regulator of TLR4 (show TLR4 Proteins) signaling.
Activates the JUN N-terminal pathway (By similarity).
mitogen-activated protein kinase kinase kinase MLK4
, mixed lineage kinase 4
, mixed lineage kinase 4-like