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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Additionally we are shipping MCC Antibodies (70) and many more products for this protein.
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The PDZ domain protein Mcc is a novel effector of non-canonical Wnt (show WNT2 Proteins) signaling during convergence and extension in zebrafish.
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (show RAB1A Proteins) in B cells
cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (show SIRT1 Proteins)
targeted by miR (show MLXIP Proteins)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.
we have shown that promoter methylation of the APC (show APC Proteins) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
MCC is a nuclear, beta-catenin-interacting protein (show CTNNBIP1 Proteins) that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal transduction.
Results identify MCC as a potential scaffold protein (show HOMER1 Proteins) regulating cell movement and able to bind Scrib, beta-catenin (show CTNNB1 Proteins) and NHERF1 (show SLC9A3R1 Proteins)/2.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein