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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Additionally we are shipping MCC Antibodies (67) and many more products for this protein.
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The PDZ domain protein Mcc is a novel effector of non-canonical Wnt (show WNT2 Proteins) signaling during convergence and extension in zebrafish.
Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (show RPS6KA2 Proteins) and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (show RPS6KA2 Proteins) = ribosomal protein S6 kinase 2 (show RPS6KA3 Proteins); MCC = mutated in colorectal cancer protein)
MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression.
Significantly, miR (show MLXIP Proteins)-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4 (show SMAD4 Proteins).
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (show RAB1A Proteins) in B cells
cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (show SIRT1 Proteins)
targeted by miR (show MLXIP Proteins)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.
we have shown that promoter methylation of the APC (show APC Proteins) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
MCC is a nuclear, beta-catenin-interacting protein (show CTNNBIP1 Proteins) that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal transduction.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein