Mycn (MYCN) ELISA Kits

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Antibodies (97) and MYCN Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top MYCN ELISA Kits at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Rat 0.312-20 ng/mL   96 Tests Log in to see 2 to 3 Days
$779.90
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$946.00
Details
Chicken
  96 Tests Log in to see 15 to 18 Days
$1,095.60
Details

More ELISA Kits for MYCN Interaction Partners

Human Mycn (MYCN) interaction partners

  1. eEF2K (show EEF2K ELISA Kits) protects MYCN overexpressing NB cells from ND in vitro and in vivo, highlighting this kinase as a critical mediator of the adaptive response of MYCN amplified NB cells to metabolic stress.

  2. Among 30 samples of brain tumor, 14 cases revealed MYCN amplification. High-protein expression of MYCN was also observed in 43.3% of patients. There was a significant correlation between MYCN gene amplification and protein expression, interestingly five case showed discrepancy between the gene amplification and protein expression.

  3. PRMT1 has a role in regulating MYCN in neuroblastoma

  4. N-myc levels appear to be modulated by the antagonistic interactions of both miR-17, as a negative regulator, and HuD, as a positive regulator in N-myc-amplified neuroblastoma cells.

  5. We also propose a model for the stabilization mechanism in which binding to Aurora-A (show AURKA ELISA Kits) alters how N-Myc interacts with SCF (show KITLG ELISA Kits)(FbxW7 (show FBXW7 ELISA Kits)) to disfavor the generation of Lys48-linked polyubiquitin (show UBB ELISA Kits) chains

  6. This study provides a novel insight for miR-221 in the control of neuroblastoma cell proliferation and tumorigenesis, suggesting potentials of miR-221 as a prognosis marker and therapeutic target for patients with MYCN overexpressing neuroblastoma.

  7. N-MYC is in the downstream-regulated gene family in reprogramming cancer metabolism under hypoxia [review]

  8. SNHG1 is up-regulated by MYCN amplification and could be a potential prognostic biomarker for high-risk neuroblastoma intervention.

  9. MYCN expression is a marker indicative of likely clinical sensitivity to mTOR inhibition in neuroblastoma cells

  10. Results show that MYCN and LSD1 co-localize at NDRG1 promoter and repress its expression in neuroblastoma cells.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. MYCN-promoted SGO1 (show SGOL1 ELISA Kits) transcription and SGO1 (show SGOL1 ELISA Kits) expression tended to be higher in MYCN- or MYC (show MYC ELISA Kits)-overexpressing cancers. Together, these findings indicate that SGO1 (show SGOL1 ELISA Kits) plays a role in the DNA damage response in interphase.

  2. interactions of NF-kappaB (show NFKB1 ELISA Kits) and N-myc with GLT-1/EAAT2 (show SLC1A2 ELISA Kits) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  3. beta-catenin (show CTNNB1 ELISA Kits) cooperates with the transcription factor Myc (show MYC ELISA Kits) to activate the progenitor renewal program.

  4. we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification

  5. miR (show MLXIP ELISA Kits)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  6. the role of N-myc in mouse lens development, was examined.

  7. Using comparative genomic hybridization, authors found that NCC-derived NBL tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL including 17q gain, 2p gain and loss of 1p36.

  8. a Mycn target gene encoding the miR (show MLXIP ELISA Kits) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  9. The findings reveal a PLK1 (show PLK1 ELISA Kits)-Fbw7 (show FBXW7 ELISA Kits)-Myc (show MYC ELISA Kits) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 ELISA Kits) inhibitors, alone or with Bcl2 (show BCL2 ELISA Kits) antagonists, as potential effective therapeutics for MYC (show MYC ELISA Kits)-overexpressing cancers.

  10. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 ELISA Kits)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

Zebrafish Mycn (MYCN) interaction partners

  1. In MYCN transgenic fish, Gab2 overexpression activated the Shp2-Ras-Erk pathway, enhanced neuroblastoma induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (show NF1 ELISA Kits) loss leads to aberrant activation of RAS (show RAB1A ELISA Kits) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1 (show NF1 ELISA Kits)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (show NF1 ELISA Kits) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen Profile

Antigen Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn (MYCN) ELISA Kits

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) antibody
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) antibody
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) antibody
  • olfactory receptor 8S1 (LOC515887) antibody
  • MYCN proto-oncogene, bHLH transcription factor (mycn) antibody
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) antibody
  • bHLHe37 antibody
  • c-nmyc antibody
  • fb57a02 antibody
  • MODED antibody
  • mycn antibody
  • mycn-a antibody
  • mycn-b antibody
  • mycna antibody
  • MYCNOT antibody
  • N-myc antibody
  • Nmuc1 antibody
  • Nmyc antibody
  • Nmyc-1 antibody
  • nmyc1 antibody
  • ODED antibody
  • wu:fb57a02 antibody
  • XN-myc antibody
  • xN-myc1 antibody
  • XNmyc antibody
  • zgc:85706 antibody

Protein level used designations for Mycn (MYCN) ELISA Kits

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPECIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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