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Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. Additionally we are shipping MLLT1 Proteins (3) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal MLLT1 Primary Antibody for ELISA, WB - ABIN542944
Thirman, Levitan, Kobayashi, Simon, Rowley: Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. in Proceedings of the National Academy of Sciences of the United States of America 1995
Show all 3 Pubmed References
Human Polyclonal MLLT1 Primary Antibody for WB - ABIN390126
Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007
Human Polyclonal MLLT1 Primary Antibody for ICC, IF - ABIN4334892
Perlman, Gadd, Arold, Radhakrishnan, Gerhard, Jennings, Huff, Guidry Auvil, Davidsen, Dome, Meerzaman, Hsu, Nguyen, Anderson, Ma, Mungall, Moore, Marra, Mullighan, Ma, Wheeler, Hampton et al.: MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours. ... in Nature communications 2015
This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies
data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia
MLL-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.
Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.
Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.
Data suggest that AT mutated protein ATM-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity.
AF9 and its homolog ENL directly interact with AF4.
MLL-ENL Interaction with CBX8 Is Required for Efficient Transformation.
Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene.
Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).
ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.
determination of the relative positions of MLL, AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines
In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing.
direct regulation of the stability of MLL1 through its cleavage by taspase1
define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs
characterization of gene structure, mapping to chromosome 17, and demonstration of an essential role in embryonic development
demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk
An intimate association between MLL and RNA pol II occurs at MLL target genes in vivo that is required for normal initiation and/or transcriptional elongation.
Overlapping expression of Af9 with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.
Even genetically complex leukemias can be reversed on inactivation of the initiating MLL fusion.
Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog
, myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
, protein ENL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1
, ENL/MLL fusion
, MLLT1/MLL fusion
, YEATS domain-containing protein 1
, leukemia-associated protein MLLT1
, myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog