anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) Antibodies

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. Additionally we are shipping MLLT1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLLT1 301119  
MLLT1 4298 Q03111
MLLT1 64144  
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Top anti-MLLT1 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-MLLT1 Antibody Titration:  1.4ug/ml  Positive Control:  Raji cell lysate MLLT1 is supported by BioGPS gene expression data to be expressed in Raji 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-MLLT1 Pab (ABIN390126) in A257 cell line lysate (35 µg/lane). MLLT1(arrow) was detected using the purified polyclonal antibody. All lanes : Anti-MLLT1 Antibody (D538) at 1:2000 dilution Lane 1: Raji whole cell lysates Lane 2: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 62 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with MLLT1 antibody ABIN214673 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-MLLT1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 2 to 3 Days
$446.88
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of MLLT1 expression in transfected 293T cell line by MLLT1 MaxPab polyclonal antibody.Lane 1: MLLT1 transfected lysate(61.49 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to MLLT1 on HeLa cell. [antibody concentration 10 ug/ml] 50 μL Log in to see 11 to 12 Days
$364.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA 50 μg Log in to see 12 to 14 Days
$686.14
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged MLLT1 is approximately 0.1ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to MLLT1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11 to 12 Days
$364.00
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$618.75
Details

Top referenced anti-MLLT1 Antibodies

  1. Human Polyclonal MLLT1 Primary Antibody for ELISA, WB - ABIN542944 : Thirman, Levitan, Kobayashi, Simon, Rowley: Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal MLLT1 Primary Antibody for WB - ABIN390126 : Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007 (PubMed)

  3. Human Polyclonal MLLT1 Primary Antibody for ICC, IF - ABIN4334892 : Perlman, Gadd, Arold, Radhakrishnan, Gerhard, Jennings, Huff, Guidry Auvil, Davidsen, Dome, Meerzaman, Hsu, Nguyen, Anderson, Ma, Mungall, Moore, Marra, Mullighan, Ma, Wheeler, Hampton et al.: MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours. ... in Nature communications 2015 (PubMed)

More Antibodies against MLLT1 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies

  2. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia

  3. MLL-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.

  4. Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.

  5. Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.

  6. Data suggest that AT mutated protein ATM-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity.

  7. AF9 and its homolog ENL directly interact with AF4.

  8. MLL-ENL Interaction with CBX8 Is Required for Efficient Transformation.

  9. Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene.

  10. Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).

  11. ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.

  12. determination of the relative positions of MLL, AF4 and ENL genes, in two lymphoblastic and two myeloid human cell lines

  13. In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 1 (MLLT1) interaction partners

  1. ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain, which recognizes acetylated histone H3.

  2. direct regulation of the stability of MLL1 through its cleavage by taspase1

  3. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia

  4. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL-mediated transformation of HPCs

  5. characterization of gene structure, mapping to chromosome 17, and demonstration of an essential role in embryonic development

  6. demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk

  7. An intimate association between MLL and RNA pol II occurs at MLL target genes in vivo that is required for normal initiation and/or transcriptional elongation.

  8. Overlapping expression of Af9 with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.

  9. Even genetically complex leukemias can be reversed on inactivation of the initiating MLL fusion.

MLLT1 Antigen Profile

Protein Summary

Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.

Gene names and symbols associated with MLLT1

  • MLLT1, super elongation complex subunit (Mllt1) antibody
  • MLLT1, super elongation complex subunit (MLLT1) antibody
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog (mllt1.L) antibody
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mllt1) antibody
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (Mllt1) antibody
  • AA407901 antibody
  • BAM11 antibody
  • ENL antibody
  • LTG19 antibody
  • MGC84026 antibody
  • MLLT1 antibody
  • YEATS1 antibody

Protein level used designations for MLLT1

myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog , myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog , protein ENL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1 , ENL/MLL fusion , MLLT1/MLL fusion , YEATS domain-containing protein 1 , leukemia-associated protein MLLT1 , myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog , trithorax

GENE ID SPECIES
301119 Rattus norvegicus
420089 Gallus gallus
447347 Xenopus laevis
485023 Canis lupus familiaris
504458 Bos taurus
702105 Macaca mulatta
740990 Pan troglodytes
100019539 Monodelphis domestica
100065400 Equus caballus
100158574 Xenopus (Silurana) tropicalis
4298 Homo sapiens
64144 Mus musculus
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