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The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface.
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the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR (show LDLR ELISA Kits)- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor (show LDLR ELISA Kits)
The long noncoding RNA RP1-13D10.2 may contribute to LDL cholesterol levels in response to statins.
Specifically, loss of IDOL increases LDLR (show LDLR ELISA Kits) distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients
Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR (show LDLR ELISA Kits).
Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (show LDLR ELISA Kits) by IDOL.
The study identified MARCH6 as a negative regulator of SREBP2 (show SREBF2 ELISA Kits)-mediated transcription and described an unexpected E3 circuit functionally linking MARCH6 and IDOL to limit uptake of low-density lipoprotein via the LDLR (show LDLR ELISA Kits) pathway.
IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.
study indicates that MYLIP p.N342S might be a pharmacogenetic marker for lipid-lowering therapy in patients with FH.
Liver-specific expression of dominant-active IDOL is associated with hypercholesterolemia and a marked elevation in atherosclerotic lesions in transgenic mice.
evidence for the existence of an LXR (show NR1H3 ELISA Kits)-IDOL-mediated internalization pathway for the LDLR (show LDLR ELISA Kits) that is distinct from that used for lipoprotein uptake
describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (show LDLR ELISA Kits) (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.
Suggest Idol as a gatekeeper of LDLR (show LDLR ELISA Kits)-dependent ApoE (show APOE ELISA Kits) and Abeta (show APP ELISA Kits) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.
Estradiol-treatment led to impaired contractile function in male cardiomyocytes only, which was characterized by increased Mylip mRNA and protein levels, and decreased myosin regulatory light chain protein.
These data identify the IDOL-LDLR (show LDLR ELISA Kits) interaction as an evolutionarily conserved mechanism for the regulation of lipid uptake and suggest that this interaction could potentially be exploited for the pharmacologic modulation of lipid metabolism.
Data show that NPC1 (show NPC1 ELISA Kits) deficiency has a major impact on VLDL metabolism in Apoe (show APOE ELISA Kits)(-/-) mice through modulation of hepatic LDL-R protein levels, and a modest one on Pcsk9 (show PCSK9 ELISA Kits) and Idol induction.
Data show that the identification of VLDLR (show VLDLR ELISA Kits) and ApoER2 (show LRP8 ELISA Kits) as Idol(Mylip) targets suggests potential roles for this LXR (show NR1H3 ELISA Kits)-inducible E3 ligase in the central nervous system in addition to lipid metabolism.
study shows the LXR (show NR1H3 ELISA Kits)-Idol(Mylip)-LDLR (show LDLR ELISA Kits) axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
E3 ubiquitin-protein ligase MYLIP-A
, myosin regulatory light chain-interacting protein A
, myosin regulatory light chain interacting protein
, e3 ubiquitin-protein ligase MYLIP-like
, E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor
, E3 ubiquitin-protein ligase MYLIP
, band 4.1 superfamily member BZF1
, cellular modulator of immune recognition (c-MIR)
, inducible degrader of the LDL-receptor
, myosin regulatory light chain-interacting protein