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The protein encoded by MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Myostatin Kits (104) and Myostatin Proteins (78) and many more products for this protein.
Showing 10 out of 293 products:
Human Monoclonal MSTN Primary Antibody for ELISA, WB - ABIN969306
Awano, Takeshima, Okizuka, Saiki, Yagi, Matsuo: Wide ranges of serum myostatin concentrations in Duchenne muscular dystrophy patients. in Clinica chimica acta; international journal of clinical chemistry 2008
Show all 2 Pubmed References
The results indicate that mstnb but not mstna plays a key role in zebrafish muscle growth. While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-kappaB (show NFKB1 Antibodies) pathway, and mstna is likely to act upstream of NF-kappaB (show NFKB1 Antibodies) at some as yet unidentified target.
improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)
the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific (show EIF3K Antibodies) proteins (MSP (show MST1 Antibodies)), and insulin (show INS Antibodies)-like growth factors (IGFs).
Epistatic analyses suggest a possible genetic interaction between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system
Findings suggest that myostatin (MSTN) function is required for regulating the appropriate growth of skeletal muscle in medaka
Higher serum myostatin levels correlated with muscle mass loss, hyperammonemia, and impaired protein synthesis, as reflected by lower serum albumin (show ALB Antibodies) levels and lower branched-chain amino acid to tyrosine ratio levels. High serum myostatin levels were also associated with a reduced OS rate in LC patients.
Study showed the expression of myostatin in healthy endometrium and a higher expression in endometriosis and endometrial cancer, suggesting myostatin involvement in human endometrial physiology and related pathologies.
Studied levels of myostatin in both serum and synovial fluid in patients with knee osteoarthritis and found both correlated with severity of knee osteoarthritis.
Myostatin (and Smad2 (show SMAD2 Antibodies)) were significantly up-regulated in the failing heart of female patients, but not male patients.
The Growth Differentiation Factor 11 (GDF11 (show GDF11 Antibodies)) and Myostatin (MSTN) in tissue specific aging.
MSTN 153Arg(R) polymorphism is associated with long distance running success.
GDF8 promotes ovarian cancer cell migration via ALK4 (show ACVR1B Antibodies)/5-SMAD2 (show SMAD2 Antibodies)/3-E-cadherin (show CDH1 Antibodies) signaling.
Results demonstrat that GDF8 stimulates the expression and secretion of CTGF (show CTGF Antibodies) in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
These studies identify distinctive structural features of GDF11 (show GDF11 Antibodies) that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.
Serum myostatin levels were significantly decreased in heart failure patients and associated with lower extremity muscle wasting.
Myostatin deletion increases lean muscle mass and results in muscle-specific (show EIF3K Antibodies) increases in endothelium-dependent vasodilation.
Indoxyl sulfate enhanced the production of myostatin by enhancing oxidative stress in skeletal muscle, leading to muscle atrophy.
Myostatin inhibition therapy for insulin (show INS Antibodies)-deficient type 1 diabetes has been proposed in an experimental model.
maternal myostatin deficiency altered fetal growth and calvarial collagen content of newborn mice and conferred a lasting impact on bone geometry and biomechanical integrity of offspring at 4 mo of age.
Mstn regulates Fndc5/Irisin (show FNDC5 Antibodies) expression and secretion through a novel miR (show MLXIP Antibodies)-34a-dependent post-transcriptional mechanism; loss of Mstn in mice leads to the increased Fndc5/Irisin (show FNDC5 Antibodies) expression, which contributes to the browning of white adipocytes
Axon diameter and myelin thickness were increased in motor axons of myostatin deficient animals.
These data illustrate the importance of lipids as a link by which MSTN deficiency can impact mitochondrial bioenergetics in skeletal muscle.
Myostatin inhibits eEF2K (show EEF2K Antibodies)-eEF2 (show EEF2 Antibodies) by regulating AMPK (show PRKAA1 Antibodies) to suppress protein synthesis.
These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin is absent and IGF1 (show IGF1 Antibodies) is in excess (show RCC1 Antibodies), and that myostatin and IGF1 (show IGF1 Antibodies) regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms.
Mstn deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle.
Report the generation of isozygous, functional myostatin (MSTN) knockout cloned pigs free of selectable marker gene (SMG (show SNRPG Antibodies)) by CRISPR/Cas9 and Cre/LoxP. CRISPR/Cas9-mediated homologous recombination (HR) was exploited to knock out (KO) one allele of MSTN in pig primary cells.
These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Antibodies) and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
Loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future.
Data show that the protein level of The protein level of myostatin (MSTN) was decreased in the mutant cloned pigs compared with the wild-type controls.
Single nucleotide polymorphisms in the MYOD1 (show MYOD1 Antibodies) and GDF8 genes are associated with genetic transcription during myogenesis in pigs.
The level of myostatin inversely correlated with miR (show MYLIP Antibodies)-27a in fat and heart of pigs and also in proliferating porcine myoblasts. Overexpression of miR (show MYLIP Antibodies)-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin.
MSTN g.435G>A and g.447A>G affected carcass traits in pigs
The genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were studied. The 435GG/447AA (show COL16A1 Antibodies) individually had significantly higher average daily gain, body weight at 70 d and 150 d , and a lower age at 110 kg than 435AA/447GG individuals.
Porcine MSTN could be upregulated by isobutyl-1-methylxanthine , MyoD (show MYOD1 Antibodies), and PPARgamma (show PPARG Antibodies) but downregulated by C/EBPalpha (show CEBPA Antibodies) and C/EBPbeta (show CEBPB Antibodies).
a vital enhancer region was identified between nucleotides -218 and -137 in promoter region of porcine myostatin
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI.
Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.
The effects of myostatin and myogenic factor 5 (show MYF5 Antibodies) polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene.
proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle.
Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells.
there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region.
A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG.
These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.
bovine myostatin is a specific target of miR (show MYLIP Antibodies)-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation
MSTN knockdown caused an upregulation (p < 0.05) of MyoD (show MYOD1 Antibodies) and downregulation (p < 0.01) of MYf5 (show MYF5 Antibodies) and FST (show FST Antibodies) expression. Moreover, we report up to approximately four fold (p < 0.001) enhanced proliferation in myoblasts after four days of culture. The anti-MSTN shRNA demonstrated in the present study could be used for the production of transgenic goats to increase the muscle mass.
The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR.
This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production.
A study of the MSTN 5' upstream region and investigation of 5'UTR (show UTS2R Antibodies) TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced.
myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts.
Polymorphisms of myostatin gene as markers associated with growth in Boer goats.
identified several mitochondrial phenotypes associated with MSTN genotype in untrained Thoroughbred horses and in addition, our findings suggest that nutritional supplementation with CoQ may aid to restore coenzyme Q activity in TT/NN horses
The effect of an Equine Repetitive Element 1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.
Myostatin mRNA but not protein was increased in skeletal muscle of obese compared with lean animals. Myostatin mRNA was increased in crest fat of obese animals and protein was undetectable. Serum myostatin was higher in obese than lean animals.
The tissue-specific presence of myostatin, the moystatin receptor (activin receptor IIB (show ACVR2B Antibodies), ActRIIB (show ACVR2B Antibodies)), follistatin (show FST Antibodies) and perilipin (show PLIN1 Antibodies), genes and proteins across a range of equine tissues, were examined.
The candidate for racing performance genomic region contained eight genes annotated by ENSEMBL, including the myostatin gene (MSTN).
Polymorphisms of the MSTN promoter region in 5 horse breeds in Poland are reported.
significant association observed between genotype and mRNA abundance for untrained horses with the C/C cohort having highest MSTN mRNA levels,T/T group lowest levels and C/T group intermediate levels; following training there was significant decrease in MSTN mRNA which was most apparent for the C/C cohort
Exon 2 of the MSTN gene, which encodes part of the TGF-beta (show TGFB1 Antibodies) pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes.
Variation at the MSTN gene influences speed in Thoroughbred horses.
This study demonstrates that the g.66493737C>T single nucleotide polymorphism in MSTN provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds.
Study successfully generated MSTN KO rabbits using CRISPR/Cas9 system with high efficiency. The rabbit showed typical phenotype of double muscle with hyperplasia or hypertrophy of muscle fiber.
Alignment of sequence data with the GenBank sequence of the rabbit MSTN gene identified three single nucleotide polymorphisms (SNPs). Significant linkage was found between the novel SNP c.373+234G>A and nine carcass composition traits.
These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.
Studied and compared mRNA levels of myostatin (MSTN), myogenin (MyoG (show MYOG Antibodies)), and myosin heavy chain (MyHC (show MYH13 Antibodies)) in skeletal muscles of two rabbit breeds with different body sizes and growth rates.
indicated that MSTN is not an important source of variability for performance traits, at least in the rabbit population
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Growth/differentiation factor 8
, growth/differentiation factor-8
, growth differentiation factor 8
, growth/differentiation factor 8