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NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping and and many more products for this protein.
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Our findings suggested that NAT2 (show SLC38A1 ELISA Kits) gene polymorphism rs1799931 was associated with decreased risk of acute myeloid leukemia (show BCL11A ELISA Kits) and was likely to be a protective factor against acute myeloid leukemia (show BCL11A ELISA Kits) development.
Study reestablished the association between NAT2 (show SLC38A1 ELISA Kits) SA and isoniazid-induced liver injury in a Singaporean population and demonstrated its clinical validity in prediction of isoniazid-induced liver injury.
In non-syndromic cleft lip with or without cleft palate, we found a significant association between the EGF61 (rs4444903) and NSCL (show NHLH1 ELISA Kits)/P (P = .01) genes. Conversely, NAT2 (show SLC38A1 ELISA Kits) (rs1799929) was not significantly different between the cases and the control group
182 Hungarian bladder cancer cases and 78 cancer-free controls were investigated. It was not possible to establish a particular impact of NAT2 (show SLC38A1 ELISA Kits)*6A and *7B genotypes (15 cases, 8%, 5 controls, 7%). GSTT1 (show GSTT1 ELISA Kits) exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls). The portion of GSTM1 (show GSTM1 ELISA Kits) negative bladder cancer patients was increased (63% cases vs. 54% controls).
Various antitubercular isoniazid dosing regimens have been proposed for NAT2 (show SLC38A1 ELISA Kits)-specific immunocompetent and immune-deficient patient populations.
Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1 (show AOX1 ELISA Kits)), NAT2 (N-acetyltransferase 2), AADAC (arylacetamide deacetylase (show AADAC ELISA Kits)), and CYP3A4 (cytochrome P450 3A4 (show CYP3A4 ELISA Kits)).
The multicolor melting curve assay described in our study is very promising for the efficient determination of NAT2 (show SLC38A1 ELISA Kits) genotype, and can facilitate the personalized dosing of isoniazid
No significant differences in the acetylator NAT2 (show SLC38A1 ELISA Kits) haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering.
In any patient who may receive INH and happens to be NAT2 (show SLC38A1 ELISA Kits) slow acetylator type, NAT2 (show SLC38A1 ELISA Kits) genotype by covert action may influence the clinical response of above drugs.
Homozygous mutant allele of NAT2 (show SLC38A1 ELISA Kits) gene at 481site may act as a predisposing factor for phenytoin intoxication among tuberculous meningitis or tuberculoma patients having seizures.
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).
N-acetyltransferase type 2
, arylamide acetylase 2
, arylamine N-acetyltransferase 2