NDRG Family Member 2 Proteins (NDRG2)

NDRG2 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping NDRG2 Antibodies (102) and NDRG2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NDRG2 29811 Q9QYG0
NDRG2 57447 Q9UN36
NDRG2 171114 Q8VBU2
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Top NDRG2 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 11 Days
$291.50
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
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Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
$2,970.00
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Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$2,970.00
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,970.00
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,982.83
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NDRG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
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Rat (Rattus) ,
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More Proteins for NDRG Family Member 2 (NDRG2) Interaction Partners

Mouse (Murine) NDRG Family Member 2 (NDRG2) interaction partners

  1. results indicate that NDRG2 deficiency leads to Attention-deficit/hyperactivity disorder (ADHD) phenotypes and that impaired astroglial glutamate clearance, a mechanism distinct from the well-established dopamine deficit hypothesis for ADHD, underlies the resultant behavioral abnormalities.

  2. Immunohistological analysis showed that the expression of NDRG2 increases dominantly in astrocytes following permanent middle cerebral artery occlusion (MCAO). Genetic deletion of Ndrg2 exhibited enhanced levels of infarct volume and accumulation of immune cells into the ipsilateral brain hemisphere following ischemia. Expression of matrix metalloproteinases (MMPs) after MCAO markedly increased in Ndrg2(-/-) mice.

  3. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.

  4. These findings provide insight into the role of NDRG2 in ischemic-hypoxic injury and provide potential targets for future clinical therapies for stroke.

  5. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis.

  6. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC)

  7. Using double knockout of NDR1 and 2 shows that NDRs acted downstream of MST1 to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  8. The expression level of NDRG2 has a causal influence on mood-related phenotypes.

  9. Ndr1/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR kinases are critically required during the early phase of organogenesis

  10. Taken together, our results suggest that the expression of NDRG2 potentially inhibits osteoclast differentiation and plays a role in modulating the signal transduction pathway responsible for osteoclastogenesis.

  11. NDRG2 is associated with decidualization during early pregnancy.

  12. NDRG2 accumulated in skeletal muscle and myoblasts in the absence of TRIM32. NDRG2 overexpression in myoblasts led to reduced cell proliferation and delayed cell cycle withdrawal during differentiation.

  13. Electroacupuncture administration can alleviate reference memory deficits and suppress N-myc downstream-regulated gene 2 upregulation in an AD transgenic mouse model

  14. Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.

  15. Ndrg2 plays a key role in reactive astrogliosis after cortical stab injury through a mechanism involving the positive regulation of IL-6/STAT3 signaling

  16. Ndr2 controls beta1-integrin phosphorylation and trafficking crucial for neurite growth.

  17. This study shows that in C2C12 myotubes Ndrg2 is a novel PGC-1alpha/ERRalpha transcriptional target.

  18. Data indicate that N-myc downstream-regulated gene 2 (NDRG2) is a novel direct target gene of farnesoid X receptor (FXR) in mouse liver and human hepatoma cell lines

  19. Loss of Ndrg2 resulted in vertebral homeotic transformations in thoracic/lumbar and lumbar/sacral transitional regions in a dose-dependent manner.

  20. Study reveals that ndrg2 is a novel gene that participates in Leydig cell apoptosis, with essential functions in testicular cells, and suggests its possible role in apoptotic Leydig cells and male fertility.

Human NDRG Family Member 2 (NDRG2) interaction partners

  1. Supporting the biological significance of the reciprocal relationship between NDRG2 and Skp2, an NDRG2low/Skp2high gene expression signature correlates with poor colorectal cancer (CRC) patient outcome and could be considered as a diagnostic marker of CRCs.

  2. We observed the knockdown of NDRG2 with miR-28-5p and miR-650 inhibitors inducing CLL cell apoptosis, yet found no increased apoptosis rates in patients with p53 aberrations following transfection with the above miRNAs inhibitors.

  3. NDRG2 knockdown promotes renal fibrosis through its effect on the protein and mRNA expression of epithelial-mesenchymal transition markers.

  4. Data show that Sentrin/SUMO specific protease (SENP2) interacts with N-myc downstream regulated gene 2 (NDRG2) and mediates the de-SUMOylation process of NDRG2.

  5. Down-regulation of NDRG2 promotes cancer cell proliferation and neoplasm invasion through regulation by microRNA-454.

  6. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.

  7. Lower expression of KLF4 and NDRG2 in colorectal cancer patients was correlated with poor overall survival. Thus, KLF4 inhibited the proliferation of colorectal cancer cells dependent on NDRG2 signaling, which provides a novel strategy for therapy and early diagnosis of colorectal cancer.

  8. NDRG2 could be a potential independent diagnostic biomarker for bladder cancer.

  9. The different NDRG2 promoter methylation and expression levels in pituitary adenoma samples showed tumor heterogeneity and indicates a potential role of this gene in pituitary adenoma pathogenesis.

  10. NDRG2 expression decreased in adriamycin resistance breast cancer cells. NDRG2 can promote adriamycin sensitivity by inhibiting proliferation, enhancing cellular damage responses, and promoting apoptosis in a p53-dependent manner.

  11. Authors investigate the clinical and pathological role of NDRG2 in human malignant tumors. The absence of NDRG2 expression is associated with oncogenic properties through the loss of its role as a tumor suppressor; NDRG2 overexpression inhibits proliferation, adhesion, and invasion, whereas its expression is low or undetectable in various cancers. [Review]

  12. These findings indicate that SUMOylation of NDRG2 is necessary for its tumor suppressor function in lung adenocarcinoma and that RNF4 increases the efficiency of this process.

  13. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis.

  14. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC)

  15. putative tumor suppressive function of NDRG2 may be confined to luminal- and basal B-type breast cancers

  16. Overexpression of NDRG2 can inhibit the proliferation.

  17. present results suggest that hypermethylation in promoter around exon 2 is functioning as essential factors of NDRG2 silencing in gastrointestinal cancers

  18. NDRG2 overexpression significantly reduced hepatoma cell proliferation and enhanced cell apoptosis under glucose limitation. Moreover, NDRG2 overexpression aggravated energy imbalance and oxidative stress by decreasing the intracellular ATP and NADPH generation and increasing ROS levels.

  19. The methylation status of the NDRG2 promoter in PBMCs is a potential noninvasive biomarker to predict the severity of liver fibrosis.

  20. Data show that downregulation of NDRG2 may play an important role in advanced hepatoblastomas.

NDRG2 Protein Profile

Protein Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with NDRG Family Member 2 Proteins (NDRG2)

  • NDRG family member 2 (ndrg2)
  • NDRG family member 2 (NDRG2)
  • N-myc downstream regulated gene 2 (Ndrg2)
  • NDRG family member 2 S homeolog (ndrg2.S)
  • NDRG family member 2 (Ndrg2)
  • AI182517 protein
  • AU040374 protein
  • im:6909381 protein
  • Ndr2 protein
  • NDRG2 protein
  • si:dkey-88n24.1 protein
  • SYLD protein
  • zgc:101847 protein

Protein level used designations for NDRG Family Member 2 Proteins (NDRG2)

protein NDRG2 , NDRG family member 2 , N-myc downstream-regulated gene 2 , N-myc downstream regulated 2 , N-myc downstream-regulated gene 2 protein , protein Ndr2 , N-myc downstream regulator 2 , NDR1-related protein NDR2 , cytoplasmic protein Ndr1 , syld709613 protein , N-myc downstream regulated gene 2 , NDRG1-related protein , antidepressant-related protein ADRG123 , N-Myc downstream regulated gene 2

GENE ID SPECIES
493281 Xenopus (Silurana) tropicalis
706990 Macaca mulatta
100351595 Oryctolagus cuniculus
29811 Mus musculus
494050 Danio rerio
380081 Xenopus laevis
57447 Homo sapiens
609390 Canis lupus familiaris
515063 Bos taurus
171114 Rattus norvegicus
100174656 Pongo abelii
100499579 Pan troglodytes
780431 Sus scrofa
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