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The protein encoded by NELL2 is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains.
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Human Polyclonal NELL2 Primary Antibody for ICC, IF - ABIN4338559
Nakamura, Oyama, Tajiri, Mizokami, Namiki, Nakamoto, Ooi: Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma. in Cancer science 2015
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
These findings identify NELL2 as an axon guidance cue and establish Robo3 (show ROBO3 Antibodies) as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.
NELL2 plays an important role in the regulation of neuronal differentiation via control of N-cadherin (show CDH2 Antibodies) expression and cell aggregation.
Nel (show HMCN1 Antibodies) interacts with a range of molecules through its different domains and exerts distinct functions.
the NELL2 gene is trans-activated by E2 and contributes to mediating the survival promoting effects of E2 via intracellular signaling pathway of ERK (show EPHB2 Antibodies)
NELL2 plays an important role as a novel suppressor in long-term potentiation in vivo in the mouse dentate gyrus
NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2.
CSF NELL2 is a potential diagnostic biomarker for TBM.
CpG islands in the NELL1 (show NELL1 Antibodies) and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma (show TSC2 Antibodies).
Cells overexpressing NELL2 increased their invasive ability and an enhancement of the effect was observed when NELL2 and E2F1 (show E2F1 Antibodies) were coexpressed in MDA-MB231 cells.
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis.
NEL-like protein 2
, protein kinase C-binding protein NELL2
, nel-like 2 homolog
, 93 kDa protein
, Mr 93 K protein
, protein NEL
, NEL-related protein 2
, neural epidermal growth factor-like 2
, NEL-like 2