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NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. Additionally we are shipping NMI Antibodies (52) and NMI Kits (5) and many more products for this protein.
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Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1 (show MAPK3 Proteins)/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC (show FAM126A Proteins)).
N-Myc (show MYCN Proteins)-interacting protein (NMI (show MYO1C Proteins)) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) in histone deacetylase (show HDAC1 Proteins)-dependent manner.
N-myc and STAT interactor sensitizes breast cancer cells to cisplatin treatment through DRAM1 dependent autophagy.
Results show that aberrant miR (show MLXIP Proteins)-29 expression may account for reduced NMI (show MYO1C Proteins) expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth.
The results showed that SARS (show SARS Proteins) coronavirus protein 6 can promote the ubiquitin-dependent proteosomal degradation of Nmi (show MYO1C Proteins).
overexpression or depletion of NMI (show MYO1C Proteins) revealed its regulation on G1/S progression and cell proliferation (both in vitro and in vivo), and this effect was partially dependent on STAT1 (show STAT1 Proteins), which interacted with and was regulated by NMI (show MYO1C Proteins).
Trim21 (show TRIM21 Proteins) regulates Nmi (show MYO1C Proteins)-IFI35 (show IFI35 Proteins) complex-mediated inhibition of innate antiviral response
Its potential function in transcriptional activation of NMI (show MYO1C Proteins).
identified NMI (show MYO1C Proteins) induction as a novel negative feedback mechanism that decreases IRE1alpha (show ERN1 Proteins)-dependent activation of JNK (show MAPK8 Proteins) and apoptosis in cytokine-exposed beta cells
Thus our work reveals a novel NMI-mediated, transcription-independent ARF induction pathway in response to cellular stresses.
We propose a novel genome-wide mechanism where myosin synergizes with Pol II-associated actin to link the polymerase machinery with permissive chromatin for transcription activation.
Our observations demonstrate specific changes in the expression of myosin IC (show MYO1C Proteins) isoform A that are concurrent with the occurrence of prostate cancer in the TRAMP (show DPT Proteins) mouse prostate cancer model that closely mimics clinical prostate cancer
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7 (show IRF7 Proteins)
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Myo1c (show MYO1C Proteins) functions as a slow transporter rather than a tension-sensitive anchor.
the novel specific NLS (show ALDH1A2 Proteins) brings to the cell nucleus not only the "nuclear" isoform of myosin I (show MYO1A Proteins) (NM1 (show MYO1C Proteins) protein) but also its "cytoplasmic" isoform (Myo1c (show MYO1C Proteins) protein)
The data suggest that Myosin 1c is involved in the cytoskeleton dynamics and membrane protein anchoring or sorting in B lymphocytes
A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
, N-mcy (and STAT) interactor
, N-myc (and STAT) interactor
, N-myc and STAT interactor
, myosin I beta
, nuclear myosin I beta
, unconventional myosin-Ic
, N-myc/STAT interactor