Naked Cuticle Homolog 1 (Drosophila) Proteins (NKD1)

In the mouse, Nkd is a Dishevelled (see DVL1\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003].. Additionally we are shipping Naked Cuticle Homolog 1 (Drosophila) Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKD1 93960 Q99MH6
NKD1 85407 Q969G9
Rat NKD1 NKD1 364952  
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Top Naked Cuticle Homolog 1 (Drosophila) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$3,228.50
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NKD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Naked Cuticle Homolog 1 (Drosophila) (NKD1) Interaction Partners

Mouse (Murine) Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells.

  2. deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage

  3. Viable mice were obtained with compound mutations in the Wnt (show WNT2 Proteins)/Dvl (show DVL1 Proteins) pathway antagonists nkd1 and nkd2 (show NKD2 Proteins).

Human Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt (show WNT2 Proteins) signaling pathway.

  2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells.

  3. HNF1A (show HNF1A Proteins)-AS1 (show PTGDR Proteins) promoted HCC (show FAM126A Proteins) cell proliferation by repressing the NKD1 and p21 (show CDKN1A Proteins) expression.

  4. Data indicate that microRNA miR (show MLXIP Proteins)-744 activated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway by targeting multiple negative regulators of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, including SFRP1 (show SFRP1 Proteins), GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR (show MLXIP Proteins)-744.

  5. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia (show BCL11A Proteins) patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia (show BCL11A Proteins).

  6. Low NKD1 expression is associated with hepatocellular carcinoma.

  7. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells.

  8. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer.

  9. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC

  10. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt (show WNT2 Proteins)/Dvl (show DVL2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling

Zebrafish Naked Cuticle Homolog 1 (Drosophila) (NKD1) interaction partners

  1. This work reveals that the zebrafish Nkd1 EF-hand is essential to balance Wnt (show WNT2 Proteins) signaling inputs and modulate the appropriate outputs, while the Drosophila-like EF-Hand primarily functions in beta-catenin (show CTNNB1 Proteins) signaling.

  2. Nkd1 activity is specifically dependent on Wnt (show WNT2 Proteins) ligand activation of the receptor. Nkd1 is recruited to the Wnt (show WNT2 Proteins) signalosome with Dvl2 (show DVL2 Proteins), where it becomes activated to move into the cytoplasm to interact with beta-catenin (show CTNNB1 Proteins), inhibiting its nuclear accumulation.

  3. Nkd1 functions as a passive antagonist of Wnt (show WNT2 Proteins) signaling, functioning only when homeostatic levels of Wnt (show WNT2 Proteins) signaling have been breached or when Wnt (show WNT2 Proteins) signaling becomes destabilized.

  4. Data demonstrate that Nkd1 binds to beta-catenin (show CTNNB1 Proteins) and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane.

  5. Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin (show CTNNB1 Proteins) nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression.

  6. data indicate that zebrafish Nkd1 and Nkd2 (show NKD2 Proteins) function to limit both canonical and non-canonical Wnt (show WNT2 Proteins) signaling

Naked Cuticle Homolog 1 (Drosophila) (NKD1) Protein Profile

Protein Summary

In the mouse, Nkd is a Dishevelled (see DVL1\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.

Gene names and symbols associated with NKD1

  • naked cuticle homolog 1 (NKD1)
  • naked cuticle 1 homolog (Drosophila) (Nkd1)
  • naked cuticle homolog 1 (Nkd1)
  • naked cuticle homolog 1 (Drosophila) (nkd1)
  • 2810434J10Rik protein
  • 9030215G15Rik protein
  • Naked1 protein
  • Nkd protein

Protein level used designations for NKD1

naked cuticle homolog 1 (Drosophila) , mNkd , mNkd1 , naked-1 , protein naked cuticle homolog 1 , Dvl-binding protein , naked cuticle-1 , naked cuticle 1 homolog , naked 1

GENE ID SPECIES
487288 Canis lupus familiaris
93960 Mus musculus
415729 Gallus gallus
85407 Homo sapiens
618586 Bos taurus
364952 Rattus norvegicus
751108 Danio rerio
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