Natriuretic Peptide Precursor C (NPPC) ELISA Kits

The protein encoded by NPPC is proteolytically processed to form a secreted hormone of the natriuretic peptide family.

list all ELISA KIts Gene Name GeneID UniProt
NPPC 4880 P23582
NPPC 114593 P55207
NPPC 18159 Q61839
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Top Natriuretic Peptide Precursor C ELISA Kits at

Showing 4 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Cow 0.094 ng/mL 0.375-24 ng/mL Typical standard curve 96 Tests 15 to 18 Days
Rat 9.375 pg/mL n/a   96 Tests 16 to 21 Days
Human 37.5 pg/mL n/a   96 Tests 16 to 21 Days
Mouse 9.375 pg/mL n/a   96 Tests 16 to 21 Days

More ELISA Kits for Natriuretic Peptide Precursor C Interaction Partners

Human Natriuretic Peptide Precursor C (NPPC) interaction partners

  1. C-type natriuretic peptide may dampen FGF-23 expression via MAPK signaling pathway in mesangial cells

  2. receptor signaling and NEP are involved in the resistance of CNP to human mesangial proliferation and Col-IV expression.

  3. This review will focus on the novel physiological functions ascribed to CNP, the receptors/signalling mechanisms involved in mediating its cardioprotective effects, and the development of therapeutics targeting CNP signalling pathways in different disease pathologies.

  4. Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an 'upstream' biomarker useful for charting myocardial ageing

  5. A link was found between circulating C-type natriuretic peptide and autonomic dysfunction in chronic kidney disease patients.

  6. The Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls.

  7. two heterozygous NPPC mutations, located in the highly conserved ring, were identified; mutations cause autosomal dominant short stature in humans

  8. This study showed that Plasma concentrations of amino-terminal proCNP are depressed in Parkinson's Disease.

  9. C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression.

  10. CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting.

  11. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)

  12. CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity

  13. CNP and FGF-23 act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase activity by CNP

  14. CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males

  15. CNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination.

  16. examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes

  17. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children.

  18. CNP/proCNP could be new markers in human prostate cancer

  19. This case supports the concept that NPPC is overexpressed because of the loss of a specific negative regulatory control in the normal chromosomal location, and demonstrates the effectiveness of targeted resequencing in the mapping of breakpoints.

  20. An increased level of NT-pro CNP is a promising non-invasive marker of hepatitis C related CLD complications and disease progression.

Pig (Porcine) Natriuretic Peptide Precursor C (NPPC) interaction partners

  1. CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals.

  2. The heart is not a major source of circulating proCNP in neonatal piglets.

  3. The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function.

  4. Inhibition of restenosis without compromising reendothelialization makes use of gene transfer into endothelial cells and muscle, smooth, vascular cells by administration of CNP.

  5. Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.

Cow (Bovine) Natriuretic Peptide Precursor C (NPPC) interaction partners

  1. Data suggest natriuretic peptide precursor C (NPPC) can regulate oogenesis/gap junction mediated communication between oocytes and cumulus cells; here, NPPC is used in non-pharmacological coordination of meiotic prophase in vitro oocyte maturation.

Mouse (Murine) Natriuretic Peptide Precursor C (NPPC) interaction partners

  1. in ovarian follicles, following the luteinizing hormone surge, NPPC levels increase initially and then decline rapidly

  2. In cultured interstitial aortic valve cells, CNP inhibited pathological differentiation via the guanylate cyclase NPR2 and not natriuretic peptide receptor 3. CNP/NPR2 signaling is a novel regulator of aortic valve development and disease.

  3. elevated in ovaries of polycystic ovary syndrome model

  4. the overexpression CNP in endothelial cells promoted BAT thermogenesis, leading to increased energy expenditure and decreased MesWAT adipocyte hypertrophy, fatty liver, insulin resistance, and inflammation in HFD-fed Tg mice.

  5. the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonataI hypoxia-ischemia brain injury.

  6. this study shows that Nppc induces sperm attraction for fertilization

  7. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)

  8. CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.

  9. The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review.

  10. Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.

  11. CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders

  12. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium

  13. CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis.

  14. Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction.

  15. CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.

  16. we show that CNP plays important region-specific roles in the GI tract of mice.

  17. CNP secreted by growing follicles is capable of stimulating preantral and antral follicle growth

  18. NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

  19. GTP-binding protein betagamma subunit-dependent potentiation of TRPV1 as novel signaling cascades recruited by CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency.

  20. These results demonstrate that lbab/lbab is a novel mouse model of chondrodysplasia caused by insufficient CNP action on endochondral ossification.

Natriuretic Peptide Precursor C (NPPC) Antigen Profile

Antigen Summary

The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic.

Gene names and symbols associated with NPPC

  • natriuretic peptide C (NPPC) antibody
  • natriuretic peptide C (Nppc) antibody
  • natriuretic peptide type C (Nppc) antibody
  • CNP antibody
  • CNP2 antibody
  • CNP3 antibody
  • lbab antibody

Protein level used designations for NPPC

C-type natriuretic peptide , natriuretic peptide precursor C , natriuretic peptide precursor type C , SVSP15 , C-type natriuretic peptide 3 , CNP

4880 Homo sapiens
114593 Rattus norvegicus
100734369 Cavia porcellus
493772 Sus scrofa
281356 Bos taurus
493773 Ovis aries
419487 Gallus gallus
610169 Canis lupus familiaris
18159 Mus musculus
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