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The protein encoded by NPPC is proteolytically processed to form a secreted hormone of the natriuretic peptide family.
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C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 (show TIMP1 ELISA Kits) progressively elevated after treatment with CNP (show CNP ELISA Kits) for 24 and 48 h, whereas declined at later time point; (3) CNP (show CNP ELISA Kits) expression was negatively correlated with MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) expression.
CNP (show CNP ELISA Kits) level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP (show CNP ELISA Kits) levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting.
Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP (show CNP ELISA Kits)-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor (show NPPA ELISA Kits) receptor B; CNP (show CNP ELISA Kits) = C-type natriuretic peptide)
CNP (show CNP ELISA Kits) may play a more important role than BNP and ANP (show NPPA ELISA Kits) related peptides, as risk marker of obesity
CNP (show CNP ELISA Kits) and FGF-23 (show FGF23 ELISA Kits) act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase (show MAPK1 ELISA Kits) activity by CNP (show CNP ELISA Kits)
CNP (show CNP ELISA Kits)/NPR-B (show NPR2 ELISA Kits) can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males
CNP (show CNP ELISA Kits) levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination.
examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes
Plasma CNP (show CNP ELISA Kits) might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children.
CNP (show CNP ELISA Kits)/proCNP could be new markers in human prostate cancer
CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals.
The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function.
Inhibition of restenosis without compromising reendothelialization makes use of gene transfer into endothelial cells and muscle, smooth, vascular cells by administration of CNP.
Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
Data suggest natriuretic peptide precursor C (NPPC) can regulate oogenesis/gap junction mediated communication between oocytes and cumulus cells; here, NPPC is used in non-pharmacological coordination of meiotic prophase in vitro oocyte maturation.
E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)
CNP (show CNP ELISA Kits) activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.
The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP (show CNP ELISA Kits))--are summarized in the review.
Connexin mimetics directed against connexin-43 (Cx43 (show GJA1 ELISA Kits) CMP (show MATN1 ELISA Kits)) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.
CNP (show CNP ELISA Kits)/NPR-C (show NPR3 ELISA Kits) pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders
Data indicate an important, previously neglected, role of NEP (show MME ELISA Kits) for regulation of luminal factors in the epididymis and suggest a novel role for CNP (show CNP ELISA Kits)/guanylyl cyclase B in the epididymal epithelium
CNP (show CNP ELISA Kits) overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis.
Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP (show CNP ELISA Kits)-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction.
CNP (show CNP ELISA Kits)/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (show AREG ELISA Kits)/EGFR (show EGFR ELISA Kits) signaling pathway suppresses this signal by downregulating Nppc expression.
we show that CNP (show CNP ELISA Kits) plays important region-specific roles in the GI tract of mice.
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic.
C-type natriuretic peptide
, natriuretic peptide precursor C
, natriuretic peptide precursor type C
, C-type natriuretic peptide 3