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in ovarian follicles, following the luteinizing hormone surge, NPPC levels increase initially and then decline rapidly
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In cultured interstitial aortic valve cells, CNP inhibited pathological differentiation via the guanylate cyclase NPR2 and not natriuretic peptide receptor 3. CNP/NPR2 signaling is a novel regulator of aortic valve development and disease.
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elevated in ovaries of polycystic ovary syndrome model
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the overexpression CNP in endothelial cells promoted BAT thermogenesis, leading to increased energy expenditure and decreased MesWAT adipocyte hypertrophy, fatty liver, insulin resistance, and inflammation in HFD-fed Tg mice.
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the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonataI hypoxia-ischemia brain injury.
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this study shows that Nppc induces sperm attraction for fertilization
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E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)
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CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.
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The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review.
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Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.
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CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders
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Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium
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CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis.
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Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction.
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CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.
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we show that CNP plays important region-specific roles in the GI tract of mice.
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CNP secreted by growing follicles is capable of stimulating preantral and antral follicle growth
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NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.
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GTP-binding protein betagamma subunit-dependent potentiation of TRPV1 as novel signaling cascades recruited by CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency.
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These results demonstrate that lbab/lbab is a novel mouse model of chondrodysplasia caused by insufficient CNP action on endochondral ossification.