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NEBL encodes a nebulin like protein that is abundantly expressed in cardiac muscle. Additionally we are shipping Nebulette Antibodies (32) and Nebulette Kits (6) and many more products for this protein.
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LASP2 may play a significant role in suppressing CRC (show CALR Proteins) progression and provided a novel biomarker for CRC (show CALR Proteins) therapy
The levels of phosphorylated FAK (show PTK2 Proteins) (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA.
predisposition to multibacillary leprosy in Vietnam is associated with CUBN (show CUBN Proteins) and NEBL common variants in the chromosome 10p13 linkage region
We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2
Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin (show VCL Proteins) and paxillin (show PXN Proteins).
Report oncogenic potential of MLL (show MLL Proteins)-NEBL and NEBL-MLL (show MLL Proteins) fusion genes in acute myeloid leukemia (show BCL11A Proteins).
Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts.
our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line.
LIM-nebulette, Lasp-1 (show LASP1 Proteins), and zyxin (show ZYX Proteins) may play an important role in the organization of focal adhesions
filamin-C (show FLNC Proteins), a known component of striated (show NSDHL Proteins) muscle Z-lines, interacts with nebulette modules
the nebulette disease causing mutations have dominant gain-of-function effects
This study showed distinct effects of NEBL mutations on sarcomere ultrastructure, cellular contractile function, and calcium homeostasis in preclinical DCM in vivo.
Actin filament binding activity may be a major contributor to the subcellular localization of lasp-2 to filopodia but is not crucial for lasp-2 recruitment to focal adhesions [lasp-2]
LIM-nebulette, Lasp-1 (show LASP1 Proteins), and zyxin (show ZYX Proteins) may play an important role in the organization of focal adhesions [LIM-nebulette]
This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.
LIM and SH3 protein
, actin-binding Z-disk protein