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NEBL encodes a nebulin like protein that is abundantly expressed in cardiac muscle. Additionally we are shipping Nebulette Antibodies (32) and Nebulette Kits (6) and many more products for this protein.
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Survival analysis suggested that overexpressed NEBL in patients with colorectal cancer was associated with a positive prognosis for overall survival.
LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy
The levels of phosphorylated FAK (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA.
predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region
We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2
Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin.
Report oncogenic potential of MLL-NEBL and NEBL-MLL fusion genes in acute myeloid leukemia.
Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts.
our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line.
LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions
filamin-C, a known component of striated muscle Z-lines, interacts with nebulette modules
the importance of the nebulette-TPM interactions in the maintenance and stability of the thin filaments.
the nebulette disease causing mutations have dominant gain-of-function effects
This study showed distinct effects of NEBL mutations on sarcomere ultrastructure, cellular contractile function, and calcium homeostasis in preclinical DCM in vivo.
Actin filament binding activity may be a major contributor to the subcellular localization of lasp-2 to filopodia but is not crucial for lasp-2 recruitment to focal adhesions [lasp-2]
LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions [LIM-nebulette]
This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.
LIM and SH3 protein
, actin-binding Z-disk protein