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NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family.
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Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage.
NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 (show STRN3 Antibodies) phase.
NEIL3-dependent modulation of DNA methylation (show HELLS Antibodies) regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction.
Data indicate that DNA glycosylases MYH (show MUTYH Antibodies), UNG2 (show CCNO Antibodies), MPG (show MPG Antibodies), NTH1, NEIL1 (show NEIL1 Antibodies), 2 and 3 on nascent DNA.
These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.
SNPs in NEIL3 are associated with impulsivity in Native American sample.
Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption .There was no gender difference for this interaction (P = 0.64 for heterogeneity). NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress.
The abnormal expressions of NEIL1 (show NEIL1 Antibodies), NEIL2 (show NEIL2 Antibodies), and NEIL3 are involved in cancer through their association with the somatic mutation load.
NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction.
Polymorphisms within FLT3 (show FLT3 Antibodies), EGFR (show EGFR Antibodies), NEIL3, and ALOX5 (show ALOX5 Antibodies) may contribute to the occurrence of GBM.
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002
DNA glycosylase FPG2
, DNA glycosylase hFPG2
, DNA glycosylase/AP lyase Neil3
, endonuclease 8-like 3
, endonuclease VIII-like 3
, nei-like protein 3