anti-Nemo-Like Kinase (NLK) Antibodies

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Additionally we are shipping Nemo-Like Kinase Proteins (11) and Nemo-Like Kinase Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLK 292804 Q6P6V0
NLK 51701 Q9UBE8
NLK 18099 O54949
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Top anti-Nemo-Like Kinase Antibodies at antibodies-online.com

Showing 10 out of 122 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-NLK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>293T cell lysate WB Suggested Anti-NLK <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control:.93T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-NLK Pab (ABIN391786) in A375 cell lysate. NLK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated FACS, IF, WB NLK-T286 (ABIN652357) western blot analysis in Y79 cell line lysates (35 µg/lane).This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image NLK antibody [N3C3] detects NLK protein at cytosol and nucleus on mouse ovary by immunohistochemical analysis. Sample: Paraffin-embedded mouse ovary. NLK antibody [N3C3] , dilution: 1:500. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-NLK Pab in A375 cell lysate. NLK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Mouse Nlk Antibody (C-term) (ABIN657850) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the Nlk antibody detected the Nlk protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using NLK antibody (ABIN5971636) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat spinal cord using NLK antibody (ABIN5971636) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of HeLa , using NLK antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277487 at 1/100 staining Mouse heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated WB NLK Antibody (ABIN1882269) western blot analysis in SiHa,Hela cell line lysates (35 µg/lane). This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details

Top referenced anti-Nemo-Like Kinase Antibodies

  1. Human Monoclonal NLK Primary Antibody for WB - ABIN1882269 : Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. in Genes & development 2004 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Nemo-Like Kinase Interaction Partners

Human Nemo-Like Kinase (NLK) interaction partners

  1. the promoters of WIF1 (show WIF1 Antibodies), NLK, and APC (show APC Antibodies) are highly methylated in the nasopharyngeal cancers (NPC (show NPC1 Antibodies)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (show MLXIP Antibodies)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1 (show WIF1 Antibodies), APC (show APC Antibodies), and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (show MLXIP Antibodies)-BART19-3p

  2. overexpression of miR (show MLXIP Antibodies)-221 decreased LEF1 (show LEF1 Antibodies) phosphorylation but increased the expression of MYCN (show MYCN Antibodies) via targeting of NLK and further regulated cell cycle, particularly in S-phase. This study provides a novel insight for miR (show MLXIP Antibodies)-221 in the control of neuroblastoma (show ARHGEF16 Antibodies) cell proliferation and tumorigenesis, suggesting potentials of miR (show MLXIP Antibodies)-221 as a prognosis marker and therapeutic target for patients with MYCN (show MYCN Antibodies) overexpressing neuroblastoma (show ARHGEF16 Antibodies).

  3. our data suggest that NLK/Nemo (show IKBKG Antibodies) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (show YAP1 Antibodies).

  4. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  5. Our results suggest that NLK inhibits transcriptional activation of Nurr1 (show NR4A2 Antibodies) gene by impeding CBP's role as a co-activator of NF-kappaB (show NFKB1 Antibodies) and CREB (show CREB1 Antibodies) in prostate cancer.

  6. The expression of NLK was negatively correlated with TCF4 (show TCF4 Antibodies) expression in lung cancers

  7. NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

  8. Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase

  9. NLK was involved in miR (show MLXIP Antibodies)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (show MLXIP Antibodies)-92b-overexpressing xenograft tumors.

  10. Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).

Mouse (Murine) Nemo-Like Kinase (NLK) interaction partners

  1. our data suggest that NLK/Nemo (show IKBKG Antibodies) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (show YAP1 Antibodies).

  2. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  3. NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (show AR Antibodies) protein, enhance its aggregation, and promote androgen receptor (show AR Antibodies)-dependent gene transcription by regulating androgen receptor (show AR Antibodies)-cofactor interactions.

  4. Nlk is a negative regulator of skeletal homeostasis.

  5. either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (show ATXN1 Antibodies)

  6. NEMO (show IKBKG Antibodies) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.

  7. Nlk suppresses osteoblastogenesis by opposing BMP/Smad (show SMAD1 Antibodies) and WNT (show WNT2 Antibodies) canonical signaling

  8. Wnt3a (show WNT3A Antibodies) stimulation led to an increase in the interaction of TAB2 (show TAB2 Antibodies) with NLK and the formation of a TAK1 (show NR2C2 Antibodies).TAB2 (show TAB2 Antibodies).NLK complex, suggesting that this TAK1 (show NR2C2 Antibodies)-TAB2 (show TAB2 Antibodies)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (show WNT2 Antibodies) signaling.

  9. NLK negatively regulates osteoblastic differentiation.

  10. NLK negatively regulates Notch (show NOTCH1 Antibodies)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

Zebrafish Nemo-Like Kinase (NLK) interaction partners

  1. Nanog (show NANOG Antibodies) suppresses the expression of vasa (show DDX4 Antibodies) by directly regulating nlk1 in the early zebrafish embryo

  2. NLK negatively regulates Notch (show NOTCH1 Antibodies)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

  3. nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.

Xenopus laevis Nemo-Like Kinase (NLK) interaction partners

  1. NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.

  2. These results provide the first evidence that p38 (show MAPK14 Antibodies) specifically regulates NLK function, which is required for anterior formation in Xenopus development.

Pig (Porcine) Nemo-Like Kinase (NLK) interaction partners

  1. These data show that porcine epidemic diarrhea virus nsp5 (show SPECC1 Antibodies) disrupts type I interferon signaling by cleaving NEMO (show IKBKG Antibodies).

Nemo-Like Kinase (NLK) Antigen Profile

Protein Summary

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Gene names and symbols associated with anti-Nemo-Like Kinase (NLK) Antibodies

  • glucose-6-phosphate isomerase (Gpi) antibody
  • nemo like kinase (NLK) antibody
  • nemo like kinase (Nlk) antibody
  • nemo-like kinase, type 1 (nlk1) antibody
  • nemo-like kinase L homeolog (nlk.L) antibody
  • nemo like kinase (nlk) antibody
  • Nemo-Like kinase (nemo-like) antibody
  • nemo-like kinase (nlk) antibody
  • AI194375 antibody
  • Amf antibody
  • Gpi1 antibody
  • nemo-like antibody
  • NLK antibody
  • nlk1 antibody
  • nlk2 antibody
  • nlkb antibody
  • RGD1561602 antibody
  • Xnlk antibody
  • zgc:111875 antibody

Protein level used designations for anti-Nemo-Like Kinase (NLK) Antibodies

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , serine/threonine-protein kinase NLK , nemo-like kinase , serine/threonine protein kinase NLK , nemo like kinase b , nemo-like kinase 2 , Nemo-like kinase , Serine/threonine-protein kinase NLK , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like

GENE ID SPECIES
292804 Rattus norvegicus
51701 Homo sapiens
18099 Mus musculus
405892 Danio rerio
414522 Xenopus laevis
417669 Gallus gallus
445934 Takifugu rubripes
491160 Canis lupus familiaris
507204 Bos taurus
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100058876 Equus caballus
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100511657 Sus scrofa
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
497961 Rattus norvegicus
100729077 Cavia porcellus
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