Nemo-Like Kinase Proteins (NLK)

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Additionally we are shipping Nemo-Like Kinase Antibodies (122) and Nemo-Like Kinase Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLK 292804 Q6P6V0
NLK 51701 Q9UBE8
NLK 18099 O54949
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Nemo-Like Kinase Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Baculovirus infected Insect Cells Human GST tag,His tag 50 μg Log in to see 20 to 21 Days
$338.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Insect Cells Human His-GST 100 μg Log in to see 11 to 12 Days
$1,502.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,501.67
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$352.75
Details
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days
$310.00
Details

NLK Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,
, , , ,
Mouse (Murine)

More Proteins for Nemo-Like Kinase (NLK) Interaction Partners

Human Nemo-Like Kinase (NLK) interaction partners

  1. the promoters of WIF1 (show WIF1 Proteins), NLK, and APC (show APC Proteins) are highly methylated in the nasopharyngeal cancers (NPC (show NPC1 Proteins)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (show MLXIP Proteins)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1 (show WIF1 Proteins), APC (show APC Proteins), and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (show MLXIP Proteins)-BART19-3p

  2. overexpression of miR (show MLXIP Proteins)-221 decreased LEF1 (show LEF1 Proteins) phosphorylation but increased the expression of MYCN (show MYCN Proteins) via targeting of NLK and further regulated cell cycle, particularly in S-phase. This study provides a novel insight for miR (show MLXIP Proteins)-221 in the control of neuroblastoma (show ARHGEF16 Proteins) cell proliferation and tumorigenesis, suggesting potentials of miR (show MLXIP Proteins)-221 as a prognosis marker and therapeutic target for patients with MYCN (show MYCN Proteins) overexpressing neuroblastoma (show ARHGEF16 Proteins).

  3. our data suggest that NLK/Nemo (show IKBKG Proteins) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (show YAP1 Proteins).

  4. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  5. Our results suggest that NLK inhibits transcriptional activation of Nurr1 (show NR4A2 Proteins) gene by impeding CBP's role as a co-activator of NF-kappaB (show NFKB1 Proteins) and CREB (show CREB1 Proteins) in prostate cancer.

  6. The expression of NLK was negatively correlated with TCF4 (show TCF4 Proteins) expression in lung cancers

  7. NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

  8. Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase

  9. NLK was involved in miR (show MLXIP Proteins)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (show MLXIP Proteins)-92b-overexpressing xenograft tumors.

  10. Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).

Mouse (Murine) Nemo-Like Kinase (NLK) interaction partners

  1. our data suggest that NLK/Nemo (show IKBKG Proteins) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (show YAP1 Proteins).

  2. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  3. NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (show AR Proteins) protein, enhance its aggregation, and promote androgen receptor (show AR Proteins)-dependent gene transcription by regulating androgen receptor (show AR Proteins)-cofactor interactions.

  4. Nlk is a negative regulator of skeletal homeostasis.

  5. either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (show ATXN1 Proteins)

  6. NEMO (show IKBKG Proteins) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.

  7. Nlk suppresses osteoblastogenesis by opposing BMP/Smad (show SMAD1 Proteins) and WNT (show WNT2 Proteins) canonical signaling

  8. Wnt3a (show WNT3A Proteins) stimulation led to an increase in the interaction of TAB2 (show TAB2 Proteins) with NLK and the formation of a TAK1 (show NR2C2 Proteins).TAB2 (show TAB2 Proteins).NLK complex, suggesting that this TAK1 (show NR2C2 Proteins)-TAB2 (show TAB2 Proteins)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (show WNT2 Proteins) signaling.

  9. NLK negatively regulates osteoblastic differentiation.

  10. NLK negatively regulates Notch (show NOTCH1 Proteins)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

Zebrafish Nemo-Like Kinase (NLK) interaction partners

  1. Nanog (show NANOG Proteins) suppresses the expression of vasa (show DDX4 Proteins) by directly regulating nlk1 in the early zebrafish embryo

  2. NLK negatively regulates Notch (show NOTCH1 Proteins)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

  3. nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.

Xenopus laevis Nemo-Like Kinase (NLK) interaction partners

  1. NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.

  2. These results provide the first evidence that p38 (show MAPK14 Proteins) specifically regulates NLK function, which is required for anterior formation in Xenopus development.

Pig (Porcine) Nemo-Like Kinase (NLK) interaction partners

  1. These data show that porcine epidemic diarrhea virus nsp5 (show SPECC1 Proteins) disrupts type I interferon (show IFNA Proteins) signaling by cleaving NEMO (show IKBKG Proteins).

Nemo-Like Kinase (NLK) Protein Profile

Protein Summary

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Gene names and symbols associated with Nemo-Like Kinase Proteins (NLK)

  • glucose-6-phosphate isomerase (Gpi)
  • nemo like kinase (NLK)
  • nemo like kinase (Nlk)
  • nemo-like kinase, type 1 (nlk1)
  • nemo-like kinase L homeolog (nlk.L)
  • nemo like kinase (nlk)
  • Nemo-Like kinase (nemo-like)
  • nemo-like kinase (nlk)
  • AI194375 protein
  • Amf protein
  • Gpi1 protein
  • nemo-like protein
  • NLK protein
  • nlk1 protein
  • nlk2 protein
  • nlkb protein
  • RGD1561602 protein
  • Xnlk protein
  • zgc:111875 protein

Protein level used designations for Nemo-Like Kinase Proteins (NLK)

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , serine/threonine-protein kinase NLK , nemo-like kinase , serine/threonine protein kinase NLK , nemo like kinase b , nemo-like kinase 2 , Nemo-like kinase , Serine/threonine-protein kinase NLK , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like

GENE ID SPECIES
292804 Rattus norvegicus
51701 Homo sapiens
18099 Mus musculus
405892 Danio rerio
414522 Xenopus laevis
417669 Gallus gallus
445934 Takifugu rubripes
491160 Canis lupus familiaris
507204 Bos taurus
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100058876 Equus caballus
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100511657 Sus scrofa
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
497961 Rattus norvegicus
100729077 Cavia porcellus
Selected quality suppliers for Nemo-Like Kinase Proteins (NLK)
Did you look for something else?