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May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity).
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SCN1A (show SCN1A Proteins) polymorphism has a dramatic effect on the proportions of neonate and adult alternative transcripts of SCN1A (show SCN1A Proteins) in adult brain tissue and, the effect of the polymorphism also appears to be modified by Nova2 expression levels.
NOVA2 uniquely regulates alternative splicing of a coordinate set of transcripts encoding key components in cortical, brainstem and spinal axon guidance/outgrowth pathways during neural differentiation, with severe functional consequences in vivo.
Together, these results demonstrate that the production of DCC (show DCC Proteins) splice variants controlled by NOVA (show HNRNPK Proteins) has a crucial function during many stages of commissural neuron development.
Phenotypic analysis of the NOVA (show HNRNPK Proteins)-deficient mice demonstrated increased adipose tissue thermogenesis and improved glycemia.
These results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the angioneurins family.
integrative network revealed combinatorial regulation by Nova (show HNRNPK Proteins) and the neuronal splicing factor (show SLU7 Proteins) Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease
Nova2 regulates an RNA switch controlling the ability of Dab1 (show DAB1 Proteins) to mediate neuronal responsiveness to reelin (show RELN Proteins) signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development.
CLIP (cross-linking and immunoprecipitation) reveals Nova (show HNRNPK Proteins) coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA
Assays of splicing intermediates of Nova (show HNRNPK Proteins)-regulated transcripts in mouse brain revealed that Nova (show HNRNPK Proteins) preferentially regulates removal of introns harbouring (or closest to) YCAY clusters
the neuron-specific splicing factor (show SLU7 Proteins) Nova (show HNRNPK Proteins) revealed extremely reproducible RNA-binding maps in multiple mouse brains
Nova1/Nova2 double knockout mice are paralyzed and fail to cluster AChRs at the neuromuscular junction, and breeding them with transgenic mice constitutively expressing Z(+) agrin (show AGRN Proteins) in motor neurons rescued AChR clustering
May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.
neuro-oncological ventral antigen 2
, neurological oncogenic ventral antigen protein
, RNA-binding protein Nova-2
, astrocytic NOVA1-like RNA-binding protein
, neuro-oncological ventral antigen 3
, neuro-oncological ventral antigen 1