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The protein encoded by NPAS1 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors.
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Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions.
Here the authors examined the crystal structures of multi-domain NPAS1-ARNT (show ARNT Proteins) and NPAS3-ARNT (show ARNT Proteins)-DNA complexes, discovering each to contain four putative ligand-binding pockets.
Npas1-expressing neurons and parvalbumin (show PVALB Proteins)-expressing neurons are two distinct functional classes of globus pallidus neurons.
The result of this study provided the evidence that NPAS1 represses the generation of specific subtypes of cortical interneurons.
a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
Npas1 can regulate myofibroblast distribution, branching morphogenesis, and neuroendocrine cell differentiation in murine embryonic lung.
These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development.
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development.
neuronal PAS domain protein 1
, PAS domain-containing protein 5
, basic-helix-loop-helix-PAS protein MOP5
, class E basic helix-loop-helix protein 11
, member of PAS protein 5
, member of PAS superfamily 5
, neuronal PAS domain-containing protein 1
, neuronal PAS1