Neuronal Pentraxin II Proteins (NPTX2)

NPTX2 encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. Additionally we are shipping Neuronal Pentraxin II Antibodies (71) and Neuronal Pentraxin II Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPTX2 4885 P47972
NPTX2 53324 O70340
NPTX2 288475  
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Top Neuronal Pentraxin II Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$662.00
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Guinea Pig His tag   1 mg Log in to see 60 to 71 Days
$3,138.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,162.50
Details

NPTX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Neuronal Pentraxin II (NPTX2) Interaction Partners

Human Neuronal Pentraxin II (NPTX2) interaction partners

  1. PTX2 (show APCS Proteins) was identified PTX2 (show APCS Proteins) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (show MSR1 Proteins)-mediated uptake by macrophages.

  2. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis.

  3. we show that NPTX2 is a marker of poor prognosis for neuroblastoma (show ARHGEF16 Proteins) patients.

  4. NPTX2 is overexpressed specifically in ccRCC primary tumors.

  5. NPTX2 repressed NF-kappaB (show NFKB1 Proteins) activity by inhibiting AKT (show AKT1 Proteins) through a p53 (show TP53 Proteins)-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB (show NFKB1 Proteins)-activated high-risk glioblastomas.

  6. Promoter methylation of NPTX2 is associated with glioblastoma.

  7. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas

  8. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired.

  9. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines.

  10. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 (show HOMER1 Proteins) rs2290639 and between NPTX2 markers rs705315 and rs1681248.

Mouse (Murine) Neuronal Pentraxin II (NPTX2) interaction partners

  1. PTX2 (show PITX2 Proteins) was identified PTX2 (show PITX2 Proteins) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (show MSR1 Proteins)-mediated uptake by macrophages.

  2. Early postnatal NPTX2(-/-)/NPTXR (show NPTXR Proteins)(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials

  3. Nptx2 contributes to the development of L-DOPA-induced dyskinesia.

  4. These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.

  5. Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.

  6. the results of this study indicated that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation.

  7. Narp prominently accumulated at excitatory synapses on parvalbumin (show PVALB Proteins)-expressing interneurons, propose that Narp recruits AMPARs at excitatory synapses onto interneurons to rebalance network excitation/inhibition dynamics following increased circuit activity

  8. data indicate that the loss of NP1 (show NPX1 Proteins)/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections

  9. Neuronal pentraxin 1 (show NPX1 Proteins) and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 (show CRP Proteins) and 2)

  10. these findings provide compelling evidence that Narp is secreted from vasopressin (show AVP Proteins) neurons in an activity-dependent fashion

Zebrafish Neuronal Pentraxin II (NPTX2) interaction partners

  1. characterized the expression of nptx2a in larvae and adults and established a transcription activator-like effector nuclease (show DCLRE1C Proteins) (TALEN)-mediated nptx2a mutant (nptx2a(-/-)) to study the role of Nptx2a in regulating structural synaptic plasticity and behavior

Neuronal Pentraxin II (NPTX2) Protein Profile

Protein Summary

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

Gene names and symbols associated with Neuronal Pentraxin II Proteins (NPTX2)

  • neuronal pentraxin 2 (NPTX2)
  • neuronal pentraxin 2 (Nptx2)
  • neuronal pentraxin II (NPTX2)
  • neuronal pentraxin 1 (NPTX1)
  • neuronal pentraxin 2a (nptx2a)
  • Narp protein
  • NP-II protein
  • np2 protein
  • nptx2 protein
  • p50 protein

Protein level used designations for Neuronal Pentraxin II Proteins (NPTX2)

apexin , neuronal activity-regulated pentaxin , neuronal pentraxin-2 , NP-II , neuro activity regulated petaxin , neuronal pentraxin II , NP2 , neuronal activity-regulated pentraxin , neuronal pentraxin 2 , AM50 , acrosomal pentaxin-like protein p50 , narp , neuronal pentraxin 2a

GENE ID SPECIES
4885 Homo sapiens
53324 Mus musculus
288475 Rattus norvegicus
416438 Gallus gallus
463562 Pan troglodytes
489866 Canis lupus familiaris
718428 Macaca mulatta
100027681 Monodelphis domestica
100081415 Ornithorhynchus anatinus
100135579 Cavia porcellus
100229849 Taeniopygia guttata
100344889 Oryctolagus cuniculus
100336779 Bos taurus
553230 Danio rerio
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