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Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor.
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Dog (Canine) Polyclonal NCEH1 Primary Antibody for ELISA - ABIN408632
Chiang, Niessen, Saghatelian, Cravatt: An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. in Chemistry & biology 2006
Human Polyclonal NCEH1 Primary Antibody for ICC, IF - ABIN4277093
Mei, Gu, Ward, Yang, Guo, He, Liu, Cao: p38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy. in The Journal of biological chemistry 2012
Authors discovered that the presence of cholesterol, LDLR (show LDLR Antibodies)-mediated cholesterol endocytosis, and cholesterol efflux are all essential to NCEH-1-mediated neuroprotection. In protecting from alpha-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers cellular reactive oxygen species in mitochondria.
Psoriasis inflammation induced microRNA targets NCEH1 in underlying subcutaneous adipose tissue.
Pioglitazone increases ABCA1 (show ABCA1 Antibodies) expression in an LXR (show NR1H3 Antibodies)-dependent manner and NCEH1 expression in an LXRalpha (show NR1H3 Antibodies)-independent manner.
Inhibition of AADACL1 activity with a variety of agents blocked platelet aggregation in response to multiple agonists; blocked activation of the small GTPase (show RACGAP1 Antibodies) RAP1 (show RABGEF1 Antibodies) and protein kinase C (PKC (show PKC Antibodies)).
NCEH1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis.
Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated neutral cholesterol ester hydrolase 1 in 20 healthy individuals.
NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
These results suggest that Nceh1 plays a dominant role over Lipe (show LIPE Antibodies) in the hydrolysis of CE and subsequent cholesterol efflux in MPMs
reducing the cholesteryl ester content of foam cells, Nceh1 may protect against the pro-apoptotic effect of oxysterols and modulate the development of atherosclerosis.
Gender difference of atherogenesis is partly accounted for activation of neutral cholesterol ester hydrolase (show LIPA Antibodies) through estrogen-dependent translocation of A-kinase type II in macrophages.
Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement.
NCEH is targeted to the ER of macrophages, where it hydrolyzes CE to deliver cholesterol for efflux out of the cells.
Genetic ablation of Nceh1 promotes foam cell formation and the development of atherosclerosis in mice.
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity).
arylacetamide deacetylase-like 1
, neutral cholesterol ester hydrolase 1
, chlorpyrifos oxon-binding protein