Nischarin (NISCH) ELISA Kits

NISCH encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. Additionally we are shipping Nischarin Antibodies (26) and Nischarin Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NISCH 64652 Q80TM9
NISCH 306255  
NISCH 11188 Q9Y2I1
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Top Nischarin ELISA Kits at

Showing 3 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.054 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
Rat < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days

Top referenced Nischarin ELISA Kits

  1. Human Nischarin ELISA Kit for Sandwich ELISA - ABIN421575 : Chen, Feng, Mo, Ding, Xie: Expression of integrin-binding protein Nischarin in metastatic breast cancer. in Molecular medicine reports 2015 (PubMed)

More ELISA Kits for Nischarin Interaction Partners

Mouse (Murine) Nischarin (NISCH) interaction partners

  1. results indicate that Nisch is an important AMPK (show PRKAA1 ELISA Kits) inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism.

  2. We identified a significant genetic interaction between Nisch and Itga5 (show ITGA5 ELISA Kits); mice heterozygous for Itga5 (show ITGA5 ELISA Kits)-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media.

  3. Nischarin inhibits neurite outgrowth by blocking PAK1 (show PAK1 ELISA Kits) activation in neurons.

  4. Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice.

  5. Data suggest that both IR1 and IR2 (imidazoline receptor 2) play roles in acquisition of behavioral responses in alcoholism; activation of IR1 and IR2 may serve as molecular targets in prevention (and possibly treatment) of alcoholism.

  6. Activation of I-1 R may activate FXR (show NR1H4 ELISA Kits) to lower plasma lipids, suggesting I-1 R as a new target for the treatment of hyperlipidemia.

  7. guanidine increases glucose uptake via an activation of imidazoline I2 receptor through AMPK (show PRKAA1 ELISA Kits) activation in skeletal muscle cell.

  8. Nisch regulates cell movement by inhibiting PAK.

  9. Data suggest that nischarin, in addition to regulating the p21-activated kinase (PAK) strand of Rac1 (show RAC1 ELISA Kits) signaling, can also regulate other links in the web of Rac1 (show RAC1 ELISA Kits) signaling pathways.

  10. Nischarin may serve as the functional I1-receptor

Human Nischarin (NISCH) interaction partners

  1. In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls.

  2. IRAS is a new mu opioid receptor (show OPRM1 ELISA Kits) interacting protein (show RIPK1 ELISA Kits) that regulates agonist-induced trafficking of mu opioid receptor (show OPRM1 ELISA Kits).

  3. Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis.

  4. Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer

  5. Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer.

  6. unctional interaction between LKB1 (show STK11 ELISA Kits) and Nischarin to inhibit cell migration and breast tumor progression

  7. Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling.

  8. Nischarin reduces alpha5 integrin expression leading to reduction of FAK (show PTK2 ELISA Kits) phosphorylation and Rac (show AKT1 ELISA Kits) GTP (show AK3 ELISA Kits) loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK (show LIMK1 ELISA Kits) signaling.

  9. Insulin receptor substrate 4 (show IRS4 ELISA Kits) associates with the protein IRAS (IRAS protein)

  10. I(1)-receptors can abrogate the primary signaling cascade activated by NGF (show NGFB ELISA Kits), most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK (show EPHB2 ELISA Kits) to its unphosphorylated state.

Nischarin (NISCH) Antigen Profile

Antigen Summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis\; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.

Gene names and symbols associated with Nischarin (NISCH) ELISA Kits

  • nischarin (NISCH) antibody
  • nischarin (Cyan7822_6841) antibody
  • nischarin S homeolog (nisch.S) antibody
  • nischarin (nisch) antibody
  • nischarin (Nisch) antibody
  • 1200007D05Rik antibody
  • 3202002H23Rik antibody
  • AW494485 antibody
  • hIRAS antibody
  • I-1 antibody
  • IR1 antibody
  • IRAS antibody
  • NISCH antibody

Protein level used designations for Nischarin (NISCH) ELISA Kits

nischarin , nischarin-like , I1R , IR1 , imidazoline receptor 1 , imidazoline receptor I-1-like protein , imidazoline-1 receptor , I-1 receptor candidate protein , imidazoline receptor I-1 , I1R candidate protein , imidazoline receptor antisera selected

415893 Gallus gallus
476594 Canis lupus familiaris
515009 Bos taurus
745886 Pan troglodytes
9736308 Cyanothece sp. PCC 7822
100036978 Xenopus laevis
100060179 Equus caballus
100156417 Sus scrofa
100170568 Xenopus (Silurana) tropicalis
100346537 Oryctolagus cuniculus
100391522 Callithrix jacchus
100457907 Pongo abelii
100540291 Meleagris gallopavo
100559383 Anolis carolinensis
100582208 Nomascus leucogenys
64652 Mus musculus
306255 Rattus norvegicus
11188 Homo sapiens
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