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The protein encoded by NOSIP may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production.
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Nosip is a novel factor critical for neural stem cell/progenitor self-renewal and neurogenesis during mouse and Xenopus development.
NOSIP mediates the monoubiquitination of the PP2A catalytic subunit and the loss of NOSIP results in an increase in PP2A activity in craniofacial tissue in NOSIP knockout mice.
While NOSIP expression was increased in Hirschsprung's disease (HSCR (show EDNRB ELISA Kits)) vs. non- HSCR (show EDNRB ELISA Kits) patients, no significant difference was observed in patients with Hirschsprung's associated enterocolitis. The increased expression of NOSIP in the aganglionic and ganglionic bowel of HSCR (show EDNRB ELISA Kits) may contribute to the development of enterocolitis by inhibiting local nitric oxide production in patients with Hirschsprung's disease.
Endogenous NOSIP reduces the enzymatic capacity of eNOS, specifically in the G(2) phase of the cell cycle by targeting eNOS to the actin cytoskeleton.
endothelial nitric oxide synthase (eNOS (show NOS3 ELISA Kits)) interacting protein (NOSIP), modulator of eNOS (show NOS3 ELISA Kits) activity by alteration of eNOS (show NOS3 ELISA Kits) subcellular localisation; high expression levels in endothelial cells and vascularized tissue.
Hydrogen peroxide down regulates endothelial dihydrofolate reductase (show DHFR ELISA Kits) expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 ELISA Kits) dysfunction.
Cdc37 (show CDC37 ELISA Kits) has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS (show NOS3 ELISA Kits)) and may play an important role in mediating the eNOS (show NOS3 ELISA Kits) protein complex formation.
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
nitric oxide synthase interacting protein
, eNOS interacting protein
, nitric oxide synthase-interacting protein
, eNOS-interacting protein