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The protein encoded by NOSIP may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Additionally we are shipping NOSIP Antibodies (53) and NOSIP Proteins (10) and many more products for this protein.
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Nosip is a novel factor critical for neural stem cell/progenitor self-renewal and neurogenesis during mouse and Xenopus development.
NOSIP mediates the monoubiquitination of the PP2A catalytic subunit and the loss of NOSIP results in an increase in PP2A activity in craniofacial tissue in NOSIP knockout mice.
While NOSIP expression was increased in Hirschsprung's disease (HSCR) vs. non- HSCR patients, no significant difference was observed in patients with Hirschsprung's associated enterocolitis. The increased expression of NOSIP in the aganglionic and ganglionic bowel of HSCR may contribute to the development of enterocolitis by inhibiting local nitric oxide production in patients with Hirschsprung's disease.
Endogenous NOSIP reduces the enzymatic capacity of eNOS, specifically in the G(2) phase of the cell cycle by targeting eNOS to the actin cytoskeleton.
endothelial nitric oxide synthase (eNOS) interacting protein (NOSIP), modulator of eNOS activity by alteration of eNOS subcellular localisation; high expression levels in endothelial cells and vascularized tissue.
Hydrogen peroxide down regulates endothelial dihydrofolate reductase expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase dysfunction.
Cdc37 has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS) and may play an important role in mediating the eNOS protein complex formation.
Nosip is a crucial factor for the development of anterior neural tissue such as the eyes and neural crest cells.
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
nitric oxide synthase interacting protein
, eNOS interacting protein
, nitric oxide synthase-interacting protein
, eNOS-interacting protein