anti-Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) Antibodies

NIPA1 encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. Additionally we are shipping NIPA1 Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NIPA1 123606 Q7RTP0
NIPA1 233280 Q8BHK1
NIPA1    
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Top anti-NIPA1 Antibodies at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$293.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: NIPA1 Antibody  - Staining of human cerebellum shows cytoplasmic positivity in Purkinje cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Dog Rabbit Un-conjugated WB   50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human urinary bladder with NIPA1 polyclonal antibody  shows strong membranous positivity in urothelial cells at 1:10-1:20 dilution. 100 μL Log in to see 11 to 12 Days
$452.00
Details

More Antibodies against NIPA1 Interaction Partners

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) interaction partners

  1. we employed an shRNA-encoding lentivirus system to inhibit SPG6 expression in AML cells including NB4 and MV4-11cells. Knockdown expression of SPG6 resulted in decreased cell growth and elevated apoptosis of these leukemia cells. Notably, SPG6 deficiency resulted in higher BMPR2 expression indicating that BMPR2 signaling contributes to AML pathogenesis.

  2. This study showed that the mutations of were detected in SPG11, ATL1, NIPA1, and ABCD1 in patient with hereditary spastic paraplegia.

  3. NIPA1 repeat expansion in the context of a C9orf72 repeat expansion would drive toward a motor neuron disease phenotype.

  4. We report here a family with a pure form of Hereditary spastic paraplegia due to a de novo transition mutation in the NIPA1 gene.

  5. study reports direct evidence of de novo c.316G>A mutation in the same hotspot of the gene in two unrelated patients who had otherwise a prototypical NIPA1-associated phenotype with a severe form of uncomplicated spastic paraplegia

  6. NIPA1 polyalanine repeat expansions are a common risk factor for ALS and modulate disease course

  7. Epilepsy might be more common in spastic paraplegia type 6 than in other forms of Hereditary spastic paraplegia because of a genetic risk factor closely linked to NIPA1.

  8. One heterozygous missense mutation of NIPA1 was identified in a complicated form of hereditary spastic paraplegia type 6 family with peripheral nerves disease

  9. a genome-wide association study of amyotrophic lateral sclerosis identified the NIPA1 locus as a candidate for more in-depth studies

  10. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes

  11. discovery of a dominant negative mutation in the NIPA1 gene in a kindred with autosomal dominant hereditary spastic paraplegia

  12. novel missense substitution in a highly conserved NIPA1 residue (G106R) which further confirms a causative link between NIPA1 mutation and autosomal dominant hereditary spastic paraplegia

  13. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales

  14. NIPA1 normally encodes a Mg2+ transporter and the loss-of function of NIPA1(SPG6) due to abnormal trafficking of the mutated protein provides the basis of the hereditary spastic paraplegia phenotype

  15. Amino acid substitution mutations implicated in a family with autosomal dominant spastic paraplegia.

  16. utations in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia and further demonstrates genotype-phenotype correlations in SPG6

  17. We propose that Hereditary spastic paraplegia-associated mutations in NIPA1 lead to cellular and functional deficits through a gain-of-function mechanism supporting the endoplasmic reticulum accumulation of toxic NIPA1 proteins.

  18. The hereditary spastic paraplegia proteins NIPA1, spastin and spartin inhibit BMP signalling by promoting BMP receptors degradation.

Mouse (Murine) Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) interaction partners

  1. indentification on mouse chromosome 7C

NIPA1 Antigen Profile

Protein Summary

This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6.

Gene names and symbols associated with NIPA1

  • non imprinted in Prader-Willi/Angelman syndrome 1 (NIPA1) antibody
  • non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human) (Nipa1) antibody
  • 1110027G09Rik antibody
  • A830014A18Rik antibody
  • FSP3 antibody
  • Spg6 antibody

Protein level used designations for NIPA1

magnesium transporter NIPA1 , non-imprinted in Prader-Willi/Angelman syndrome 1 , non-imprinted in Prader-Willi/Angelman syndrome region protein 1 , spastic paraplegia 6 protein , non-imprinted in Prader-Willi/Angelman syndrome region protein 1 homolog , spastic paraplegia 6 homolog

GENE ID SPECIES
123606 Homo sapiens
233280 Mus musculus
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