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Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
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Human Polyclonal NCAPD2 Primary Antibody for IP, WB - ABIN151115
Manning, Longworth, Dyson: Loss of pRB causes centromere dysfunction and chromosomal instability. in Genes & development 2010
The authors propose that histone H3 threonine 118 phosphorylation via Aurora-A alters the chromatin structure during specific phases of mitosis to promote timely condensin I and cohesin disassociation, which is essential for effective chromosome segregation.
Study has shown that both rs7311174 and rs2072374 in the NCAPD2 gene are associated with Parkinson's disease in a Han Chinese population.
Data show that that DNA repear process is dictated by PARP1 (show PARP1 Antibodies) through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.
Data show the CNAP1 C-terminal region defines a novel histone-binding domain that is responsible for targeting CNAP1, and possibly condensin, to mitotic chromosomes.
Knock-down of a condensin subunit protein or YY1 (show YY1 Antibodies) reduced rearrangement of Igkappa Vkappa genes suggesting a direct role for YY1 (show YY1 Antibodies)-condensin complexes in Igkappa locus structure and rearrangement.
The characterization of two novel E2F (show E2F1 Antibodies) target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk (show MELK Antibodies)) is reported.
Loss of the interaction partners CAP-H (show NCAPH Antibodies) and CAP-D2 causes cytoplasmic mislocalization of CAP-G throughout mitosis.
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.
, chromosome condensation related SMC associated protein 1
, chromosome condensation-related SMC-associated protein 1
, chromosome-associated protein D2
, condensin complex subunit 1
, 13S condensin XCAP-D2 subunit
, chromosome assembly protein XCAP-D2
, non-SMC condensin I complex, subunit D2