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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. Additionally we are shipping Nucleoporin 54kDa Antibodies (20) and and many more products for this protein.
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Mutations within the footprinted region of Nup54 polymers blocked both polymerization and binding by the PRn (show NARFL Proteins) poly-dipeptide. 1,6-hexanediol melted FG domain polymers in vitro and reversed PRn (show NARFL Proteins)-mediated enhancement of the nuclear pore permeability barrier, suggesting that toxicity of the PRn (show NARFL Proteins) poly-dipeptide results in part from its ability to lock the FG repeats of nuclear pore proteins in the polymerized state.
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.
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